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Literature summary for 2.6.1.7 extracted from

  • Akladios, F.N.; Nadvi, N.A.; Park, J.; Hanrahan, J.R.; Kapoor, V.; Gorrell, M.D.; Church, W.B.
    Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I (2012), Bioorg. Med. Chem. Lett., 22, 1579-1581.
    View publication on PubMed
Search for more literature for 2.6.1.7

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-(2-carboxyethyl)-5-chloro-1H-indole-2-carboxylic acid
-
 Homo sapiens
3-(2-carboxyethyl)-5-nitro-1H-indole-2-carboxylic acid
-
 Homo sapiens
5-(2-(3-chlorophenyl)hydrazono)-6-ethoxy-6-oxohexanoic acid
-
 Homo sapiens
5-(2-(4-bromophenyl)hydrazono)-6-ethoxy-6-oxohexanoic acid
-
 Homo sapiens
5-(2-(4-chlorophenyl) hydrazono)-6-ethoxy-6-oxohexanoic acid
-
 Homo sapiens
5-bromo-3-(2-carboxyethyl)-1H-indole-2-carboxylic acid
-
 Homo sapiens
6-ethoxy-5-(2-(4-iodophenyl)hydrazono)-6-oxohexanoic acid
-
 Homo sapiens
6-ethoxy-5-(2-(4-methoxyphenyl)hydrazono)-6-oxohexanoic acid
-
 Homo sapiens
6-ethoxy-5-(2-(4-nitrophenyl)hydrazono)-6-oxohexanoic acid
-
 Homo sapiens
6-ethoxy-6-oxo-5-(2-p-tolylhydrazono)hexanoic acid
-
 Homo sapiens
Indole-3-propionic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
kynurenine aminotransferase-I
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(2-(4-chlorophenyl) hydrazono)-6-ethoxy-6-oxohexanoic acid
0.02
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(2-(3-chlorophenyl)hydrazono)-6-ethoxy-6-oxohexanoic acid
0.021
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-(2-(4-bromophenyl)hydrazono)-6-ethoxy-6-oxohexanoic acid
0.033
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 6-ethoxy-6-oxo-5-(2-p-tolylhydrazono)hexanoic acid
0.034
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 6-ethoxy-5-(2-(4-iodophenyl)hydrazono)-6-oxohexanoic acid
0.043
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 6-ethoxy-5-(2-(4-methoxyphenyl)hydrazono)-6-oxohexanoic acid
0.14
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens Indole-3-propionic acid
0.179
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 6-ethoxy-5-(2-(4-nitrophenyl)hydrazono)-6-oxohexanoic acid
0.271
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-bromo-3-(2-carboxyethyl)-1H-indole-2-carboxylic acid
0.293
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-(2-carboxyethyl)-5-chloro-1H-indole-2-carboxylic acid
0.666
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-(2-carboxyethyl)-5-nitro-1H-indole-2-carboxylic acid