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Literature summary for 2.6.1.7 extracted from

  • Han, Q.; Robinson, H.; Cai, T.; Tagle, D.A.; Li, J.
    Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K (2009), J. Med. Chem., 52, 2786-2793.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with 3-indolepropionic acid or DL-indole-3-lactic acid, hanging drop vapor diffusion method, using 22% (w/v) PEG 4000, 0.2 M sodium acetate, 0.1 M Tris, pH 8.5 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-indolepropionic acid
-
Homo sapiens
DL-indole-3-lactic acid
-
Homo sapiens
indole-3-acetic acid
-
Homo sapiens
indole-3-pyruvic acid
-
Homo sapiens
additional information glycerol is not a functional inhibitor of KAT I Homo sapiens
trans-3-indolacrylic acid
-
Homo sapiens
Tris
-
Homo sapiens
tryptophan
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16773
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxobutyrate
-
Homo sapiens kynurenic acid + 2-aminobutanoate + H2O
-
?
additional information 3-indolepropionic acid and DL-indole-3-lactic acid are no substrates of kynurenine aminotransferase I Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
KAT I
-
Homo sapiens
kynurenine aminotransferase I
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens