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Literature summary for 2.6.1.7 extracted from

  • Han, Q.; Li, J.
    pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I (2004), Eur. J. Biochem., 271, 4804-4814.
    View publication on PubMed
Search for more literature for 2.6.1.7

Inhibitors

Inhibitors Comment Organism Structure
cysteine
-
 Homo sapiens
Indole-3-pyruvate 5 mM, complete inhibition Homo sapiens
Tris Tris buffer pH 7.5, low activity, pH 8.0, no activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7
-
 L-cysteine pH 7.5, 45°C Homo sapiens
0.8
-
 phenylpyruvate pH 7.5, 45°C Homo sapiens
1
-
 2-oxoisocaproate pH 7.5, 45°C Homo sapiens
1.2
-
 L-tryptophan pH 7.5, 45°C Homo sapiens
1.5
-
 glyoxylate pH 7.5, 45°C Homo sapiens
1.7
-
 L-phenylalanine pH 7.5, 45°C Homo sapiens
2.5
-
 Mercaptopyruvate pH 7.5, 45°C Homo sapiens
2.8
-
 L-glutamine pH 7.5, 45°C Homo sapiens
3
-
 2-oxobutanoate pH 7.5, 45°C Homo sapiens
3.2
-
 L-tyrosine pH 7.5, 45°C Homo sapiens
4.2
-
 oxaloacetate pH 7.5, 45°C Homo sapiens
4.7
-
 L-kynurenine pH 7.5, 45°C Homo sapiens
5.4
-
 L-histidine pH 7.5, 45°C Homo sapiens
6.4
-
 L-methionine pH 7.5, 45°C Homo sapiens
7.6
-
 L-leucine pH 7.5, 45°C Homo sapiens
12.1
-
 pyruvate pH 7.5, 45°C Homo sapiens
21.3
-
 2-aminobutanoate pH 7.5, 45°C Homo sapiens
23.1
-
 L-asparagine pH 7.5, 45°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, SDS-PAGE, x * 47875, calculated Homo sapiens
47875
-
 x * 46000, SDS-PAGE, x * 47875, calculated Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 expression in Sf9 system
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-asparagine + 2-oxobutanoate
-
 Homo sapiens 2-oxosuccinamic acid + 2-aminobutanoate
-
 ?
L-cysteine + 2-oxobutanoate
-
 Homo sapiens 2-aminobutanoate + 3-mercapto-2-oxopropanoate
-
 ?
L-glutamine + 2-oxobutanoate
-
 Homo sapiens 2-oxoglutarate + 2-aminobutanoate
-
 ?
L-histidine + 2-oxobutanoate
-
 Homo sapiens 3-(1H-imidazol-4-yl)-2-oxopropanoate + 2-aminobutanoate
-
 ?
L-kynurenine + 2-oxobutanoate
-
 Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminobutanoate
-
 ?
L-kynurenine + 2-oxoisocaproate
-
 Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine
-
 ?
L-kynurenine + glyoxylate
-
 Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
 ?
L-kynurenine + mercaptopyruvate
-
 Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine
-
 ?
L-kynurenine + oxaloacetate
-
 Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminosuccinate
-
 ?
L-kynurenine + phenylpyruvate
-
 Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine
-
 ?
L-kynurenine + pyruvate
-
 Homo sapiens 4-(2-aminophenyl)2,4-dioxobutanoate + L-alanine
-
 ?
L-leucine + 2-oxobutanoate
-
 Homo sapiens 2-oxoisocaproate + 2-aminobutanoate
-
 ?
L-methionine + 2-oxobutanoate
-
 Homo sapiens 4-methylsulfanyl-2-oxobutanoate + 2-aminobutanoate
-
 ?
L-phenylalanine + 2-oxobutanoate
-
 Homo sapiens phenylpyruvate + 2-aminobutanoate
-
 ?
L-tryptophan + 2-oxobutanoate
-
 Homo sapiens 3-indole-2-oxopropanoate + 2-aminobutanoate
-
 ?
L-tyrosine + 2-oxobutanoate
-
 Homo sapiens 3-(4-hydroxyphenyl)-2-oxopropanoate + 2-aminobutanoate
-
 ?
additional information very bad substrate: L-glycine, L-alanine, L-arginine, L-serine, L-lysine, no substrate: l-threonine, L-isoleucine, L-aspartate, L-glutamate, L-valine, L-aminoadipate Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, SDS-PAGE, x * 47875, calculated Homo sapiens

Synonyms

Synonyms Comment Organism
KAT-I
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
9.6
-
 L-cysteine pH 7.5, 45°C Homo sapiens
14.4
-
 L-asparagine pH 7.5, 45°C Homo sapiens
29
-
 pyruvate pH 7.5, 45°C Homo sapiens
38.3
-
 2-aminobutanoate pH 7.5, 45°C Homo sapiens
43.1
-
 L-tryptophan pH 7.5, 45°C Homo sapiens
91
-
 L-phenylalanine pH 7.5, 45°C Homo sapiens
91
-
 L-tyrosine pH 7.5, 45°C Homo sapiens
110
-
 phenylpyruvate pH 7.5, 45°C Homo sapiens
143
-
 oxaloacetate pH 7.5, 45°C Homo sapiens
143
-
 L-histidine pH 7.5, 45°C Homo sapiens
201
-
 L-kynurenine pH 7.5, 45°C Homo sapiens
215
-
 L-methionine pH 7.5, 45°C Homo sapiens
234
-
 2-oxobutanoate pH 7.5, 45°C Homo sapiens
234
-
 Mercaptopyruvate pH 7.5, 45°C Homo sapiens
263
-
 glyoxylate pH 7.5, 45°C Homo sapiens
296
-
 2-oxoisocaproate pH 7.5, 45°C Homo sapiens
339
-
 L-leucine pH 7.5, 45°C Homo sapiens
440
-
 L-glutamine pH 7.5, 45°C Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7.5 9
-
 Homo sapiens