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Literature summary for 2.6.1.7 extracted from

  • Guidetti, P.; Okuno, E.; Schwarcz, R.
    Characterization of rat brain kynurenine aminotransferases I and II (1997), J. Neurosci. Res., 50, 457-465.
    View publication on PubMed
Search for more literature for 2.6.1.7

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxykynurenine 0.6 mM, 54% inhibition of KAT I, 88% inhibition of KAT II Rattus norvegicus
alpha-aminoadipate strong inhibition of KAT II Rattus norvegicus
glutamine strong inhibition of KAT I Rattus norvegicus
L-phenylalanine strong inhibition of KAT I Rattus norvegicus
L-tryptophan strong inhibition of KAT I Rattus norvegicus
additional information KAT I is not inhibited by quisqualate Rattus norvegicus
quisqualate 0.52 mM, 50% inhibition of KAT II, 2 mM, 80% inhibition Rattus norvegicus
S-dichlorovinyl-L-cysteine 2 mM, 90% inhibition of KAT I and KAT II Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
 2-oxoglutarate pH 9.5, 37°C, KAT I Rattus norvegicus
0.053
-
 pyruvate pH 9.5, 37°C, KAT I Rattus norvegicus
0.717
-
 pyruvate pH 7.0, 37°C, KAT II Rattus norvegicus
0.879
-
 2-oxoglutarate pH 7.0, 37°C, KAT II Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 KAT I and KAT II
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sepharose, ammonium sulfate, Sephadex G-25, partial purification of KAT I and KAT II Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain KAT I and KAT II Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate KAT II shows equal activity with 2-oxoglutarate and pyruvate, KAT I shows lower activity with 2-oxoglutarate than with pyruvate, ratio of KAT I to KAT II in normal brain is approx. 1/4 Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
L-kynurenine + pyruvate
-
 Rattus norvegicus kynurenic acid + L-alanine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
More brain KAT I is identical with glutamine transferase K Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5 KAT II Rattus norvegicus
9 9.5 KAT I Rattus norvegicus