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Literature summary for 2.6.1.7 extracted from

  • Jakoby, W.B.; Bonner, D.M.
    Kynurenine transaminase from Neurospora (1956), J. Biol. Chem., 221, 689-695.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-kynurenine inhibition above 5 mM Neurospora crassa
pyridoxal 5'-phosphate at high concentrations Neurospora crassa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7
-
pyruvate pH 7.5, 37°C, cosubstrate L-kynurenine Neurospora crassa
0.7
-
2-oxoglutarate pH 7.5, 37°C, cosubstrate L-kynurenine Neurospora crassa
1.5
-
L-kynurenine pH 7.5, 37°C Neurospora crassa

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5
-
L-kynurenine Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-3-hydroxykynurenine + 2-oxoglutarate
-
Neurospora crassa xanthurenic acid + L-glutamate
-
?
L-kynurenine + 2-oxobutyrate less effective than 2-oxoglutarate Neurospora crassa kynurenic acid + 2-aminobutanoate + H2O
-
?
L-kynurenine + 2-oxoglutarate no activity with D-kynureinine Neurospora crassa kynurenic acid + L-glutamate + H2O
-
?
L-kynurenine + 2-oxoisopentanoate poor substrate Neurospora crassa kynurenic acid + 2-aminoisopentanoate + H2O
-
?
L-kynurenine + 2-oxopentanoate less effective than 2-oxoglutarate Neurospora crassa kynurenic acid + L-norvaline + H2O
-
?
L-kynurenine + 3-indole-2-oxopropanoate
-
Neurospora crassa kynurenic acid + L-tryptophan + H2O
-
?
L-kynurenine + 3-methyl-2-oxopentanoate poor substrate Neurospora crassa kynurenic acid + L-isoleucine + H2O
-
?
L-kynurenine + 3-phenyl-2-oxopropanoate
-
Neurospora crassa kynurenic acid + L-phenylalanine + H2O
-
?
L-kynurenine + pyruvate
-
Neurospora crassa kynurenic acid + L-alanine + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Neurospora crassa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Neurospora crassa

pH Range

pH Minimum pH Maximum Comment Organism
6.2 9.2 approx. half-maximal activity at pH 6.2, approx. 60% of maximal activity at pH 9.2 Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
additional information pyridoxamine 5'-phosphate is not a cofactor Neurospora crassa
pyridoxal 5'-phosphate Km-value: 0.001 mM Neurospora crassa