Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-kynurenine | inhibition above 5 mM | Neurospora crassa | |
pyridoxal 5'-phosphate | at high concentrations | Neurospora crassa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
pyruvate | pH 7.5, 37°C, cosubstrate L-kynurenine | Neurospora crassa | |
0.7 | - |
2-oxoglutarate | pH 7.5, 37°C, cosubstrate L-kynurenine | Neurospora crassa | |
1.5 | - |
L-kynurenine | pH 7.5, 37°C | Neurospora crassa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neurospora crassa | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.5 | - |
L-kynurenine | Neurospora crassa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3-hydroxykynurenine + 2-oxoglutarate | - |
Neurospora crassa | xanthurenic acid + L-glutamate | - |
? | |
L-kynurenine + 2-oxobutyrate | less effective than 2-oxoglutarate | Neurospora crassa | kynurenic acid + 2-aminobutanoate + H2O | - |
? | |
L-kynurenine + 2-oxoglutarate | no activity with D-kynureinine | Neurospora crassa | kynurenic acid + L-glutamate + H2O | - |
? | |
L-kynurenine + 2-oxoisopentanoate | poor substrate | Neurospora crassa | kynurenic acid + 2-aminoisopentanoate + H2O | - |
? | |
L-kynurenine + 2-oxopentanoate | less effective than 2-oxoglutarate | Neurospora crassa | kynurenic acid + L-norvaline + H2O | - |
? | |
L-kynurenine + 3-indole-2-oxopropanoate | - |
Neurospora crassa | kynurenic acid + L-tryptophan + H2O | - |
? | |
L-kynurenine + 3-methyl-2-oxopentanoate | poor substrate | Neurospora crassa | kynurenic acid + L-isoleucine + H2O | - |
? | |
L-kynurenine + 3-phenyl-2-oxopropanoate | - |
Neurospora crassa | kynurenic acid + L-phenylalanine + H2O | - |
? | |
L-kynurenine + pyruvate | - |
Neurospora crassa | kynurenic acid + L-alanine + H2O | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Neurospora crassa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Neurospora crassa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.2 | 9.2 | approx. half-maximal activity at pH 6.2, approx. 60% of maximal activity at pH 9.2 | Neurospora crassa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | pyridoxamine 5'-phosphate is not a cofactor | Neurospora crassa | |
pyridoxal 5'-phosphate | Km-value: 0.001 mM | Neurospora crassa |