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Literature summary for 2.6.1.7 extracted from

  • Mason, M.
    Kynurenine transaminase of rat kidney: a study of coenzyme dissociation (1957), J. Biol. Chem., 227, 61-68.
    View publication on PubMed
Search for more literature for 2.6.1.7

General Stability

General Stability Organism
alcohol fractionation inactivates Rattus norvegicus
ammonium sulfate fractionation inactivates Rattus norvegicus
dialysis against phosphate buffer inactivates, 2-oxoglutarate protects to some extent Rattus norvegicus
freeze-thawing inactivates Rattus norvegicus
slightly acidic buffer solutions inactivate, pyridoxal phosphate or pyridoxamine phosphate restores activity, 2-oxoglutarate protects Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification of kynurenine apotransaminase Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate
-
 Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
L-kynurenine + 2-oxoisohexanoate less effective than 2-oxoglutarate Rattus norvegicus kynurenic acid + 2-aminoisohexanoate + H2O
-
 ?
L-kynurenine + oxaloacetate
-
 Rattus norvegicus kynurenic acid + L-aspartate + H2O
-
 ?
L-kynurenine + pyruvate less effective than 2-oxoglutarate Rattus norvegicus kynurenic acid + L-alanine + H2O
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
 phosphate buffer, pH 6.3, inactivation within a few min, pyridoxal phosphate restores activity, only slow inactivation at pH 7.4, 2-oxoglutarate protects Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus