Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.57 extracted from

  • Whitaker, R.J.; Gaines, C.G.; Jensen, R.A.
    A multispecific quintet of aromatic aminotransferases that overlap different biochemical pathways in Pseudomonas aeruginosa (1982), J. Biol. Chem., 257, 13550-13556.
    View publication on PubMed
Search for more literature for 2.6.1.57

General Stability

General Stability Organism
aromatic aminotransferase AT-1 is unstable to freeze-thaw treatment. With a single freeze-thaw cycle the enzyme loses about 50% of its original activity. Additional freeze-thaw treatments completely inactivate AT-1 Pseudomonas aeruginosa
aromatic aminotransferase AT-2 is stable to repeated freeze-thaw treatments Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
 aromatic aminotransferase AT-1, gel filtration Pseudomonas aeruginosa
64000
-
 aromatic aminotransferase AT-2, gel filtration Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis ?
-
 ?
additional information Pseudomonas aeruginosa the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
 aromatic aminotransferase AT-1
-
Pseudomonas aeruginosa
-
 aromatic aminotransferase AT-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa L-glutamate + 2-oxosuccinic acid
-
 ?
2-oxoglutarate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa L-glutamate + 2-oxosuccinic acid
-
 ?
2-oxoglutarate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Glu + 2-oxoglutarate
-
 ?
2-oxoglutarate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Glu + 2-oxoglutarate
-
 ?
2-oxoglutarate + L-Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa L-Glu + phenylpyruvate
-
 ?
2-oxoglutarate + L-Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa L-Glu + phenylpyruvate
-
 ?
2-oxoglutarate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa L-glutamate + 4-hydroxyphenylpyruvate
-
 ?
2-oxoglutarate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa L-glutamate + 4-hydroxyphenylpyruvate
-
 ?
4-hydroxyphenylpyruvate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa Tyr + 2-oxosuccinate
-
 ?
4-hydroxyphenylpyruvate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa Tyr + 2-oxosuccinate
-
 ?
4-hydroxyphenylpyruvate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Tyr + 2-oxoglutarate
-
 ?
4-hydroxyphenylpyruvate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Tyr + 2-oxoglutarate
-
 ?
4-hydroxyphenylpyruvate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa tyr + phenylpyruvate
-
 ?
4-hydroxyphenylpyruvate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa tyr + phenylpyruvate
-
 ?
4-hydroxyphenylpyruvate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa Tyr + 4-hydroxyphenylpyruvate
-
 ?
4-hydroxyphenylpyruvate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa Tyr + 4-hydroxyphenylpyruvate
-
 ?
additional information role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis Pseudomonas aeruginosa ?
-
 ?
additional information the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis Pseudomonas aeruginosa ?
-
 ?
oxaloacetate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + oxaloacetate
-
 ?
oxaloacetate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + oxaloacetate
-
 ?
oxaloacetate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + 2-oxoglutarate
-
 ?
oxaloacetate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + 2-oxoglutarate
-
 ?
oxaloacetate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + phenylpyruvate
-
 ?
oxaloacetate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + phenylpyruvate
-
 ?
oxaloacetate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa Asp + 4-hydroxyphenylpyruvate
-
 ?
oxaloacetate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa Asp + 4-hydroxyphenylpyruvate
-
 ?
phenylpyruvate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + 2-oxosuccinate
-
 ?
phenylpyruvate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + 2-oxosuccinate
-
 ?
phenylpyruvate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + 2-oxoglutarate
-
 ?
phenylpyruvate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + 2-oxoglutarate
-
 ?
phenylpyruvate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + phenylpyruvate
-
 ?
phenylpyruvate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + phenylpyruvate
-
 ?
phenylpyruvate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
 ?
phenylpyruvate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
 ?
prephenate + Asp aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + 2-oxosuccinate
-
 ?
prephenate + Asp aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + 2-oxosuccinate
-
 ?
prephenate + Glu aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + 2-oxoglutarate
-
 ?
prephenate + Glu aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + 2-oxoglutarate
-
 ?
prephenate + Phe aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + phenylpyruvate
-
 ?
prephenate + Phe aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + phenylpyruvate
-
 ?
prephenate + Tyr aromatic aminotransferase AT-1 Pseudomonas aeruginosa arogenate + 4-hydroxyphenylpyruvate
-
 ?
prephenate + Tyr aromatic aminotransferase AT-2 Pseudomonas aeruginosa arogenate + 4-hydroxyphenylpyruvate
-
 ?

Synonyms

Synonyms Comment Organism
aromatic aminotransferase AT-1
-
 Pseudomonas aeruginosa
aromatic aminotransferase AT-2
-
 Pseudomonas aeruginosa
AT-1
-
 Pseudomonas aeruginosa
AT-2
-
 Pseudomonas aeruginosa

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
 inactivated at, aromatic aminotransferase AT-1 loses activity much more precipitously than does aromatic aminotransferase AT-2 Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
 L-glutamate, aromatic aminotransferase AT-1 Pseudomonas aeruginosa
7
-
 L-Phe, L-Tyr, L-Asp or L-Glu as substrate, aromatic aminotransferase AT-2 Pseudomonas aeruginosa
7.6
-
 L-Asp, aromatic aminotransferase AT-1 Pseudomonas aeruginosa
8.4
-
 L-Phe or L-Tyr, aromatic aminotransferase AT-1 Pseudomonas aeruginosa