BRENDA - Enzyme Database show
show all sequences of 2.6.1.57

A multispecific quintet of aromatic aminotransferases that overlap different biochemical pathways in Pseudomonas aeruginosa

Whitaker, R.J.; Gaines, C.G.; Jensen, R.A.; J. Biol. Chem. 257, 13550-13556 (1982)

Data extracted from this reference:

General Stability
General Stability
Organism
aromatic aminotransferase AT-1 is unstable to freeze-thaw treatment. With a single freeze-thaw cycle the enzyme loses about 50% of its original activity. Additional freeze-thaw treatments completely inactivate AT-1
Pseudomonas aeruginosa
aromatic aminotransferase AT-2 is stable to repeated freeze-thaw treatments
Pseudomonas aeruginosa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
64000
-
aromatic aminotransferase AT-1, gel filtration; aromatic aminotransferase AT-2, gel filtration
Pseudomonas aeruginosa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Pseudomonas aeruginosa
role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis
?
-
-
-
additional information
Pseudomonas aeruginosa
the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas aeruginosa
-
aromatic aminotransferase AT-1; aromatic aminotransferase AT-2
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxoglutarate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
L-glutamate + 2-oxosuccinic acid
-
-
-
?
2-oxoglutarate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
L-glutamate + 2-oxosuccinic acid
-
-
-
?
2-oxoglutarate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Glu + 2-oxoglutarate
-
-
-
?
2-oxoglutarate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Glu + 2-oxoglutarate
-
-
-
?
2-oxoglutarate + L-Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
L-Glu + phenylpyruvate
-
-
-
?
2-oxoglutarate + L-Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
L-Glu + phenylpyruvate
-
-
-
?
2-oxoglutarate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
?
2-oxoglutarate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Tyr + 2-oxosuccinate
-
-
-
?
4-hydroxyphenylpyruvate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Tyr + 2-oxosuccinate
-
-
-
?
4-hydroxyphenylpyruvate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Tyr + 2-oxoglutarate
-
-
-
?
4-hydroxyphenylpyruvate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Tyr + 2-oxoglutarate
-
-
-
?
4-hydroxyphenylpyruvate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
tyr + phenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
tyr + phenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Tyr + 4-hydroxyphenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Tyr + 4-hydroxyphenylpyruvate
-
-
-
?
additional information
role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis
662080
Pseudomonas aeruginosa
?
-
-
-
-
additional information
the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis
662080
Pseudomonas aeruginosa
?
-
-
-
-
oxaloacetate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + oxaloacetate
-
-
-
?
oxaloacetate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + oxaloacetate
-
-
-
?
oxaloacetate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + 2-oxoglutarate
-
-
-
?
oxaloacetate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + 2-oxoglutarate
-
-
-
?
oxaloacetate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + phenylpyruvate
-
-
-
?
oxaloacetate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + phenylpyruvate
-
-
-
?
oxaloacetate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + 4-hydroxyphenylpyruvate
-
-
-
?
oxaloacetate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + 4-hydroxyphenylpyruvate
-
-
-
?
phenylpyruvate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + 2-oxosuccinate
-
-
-
?
phenylpyruvate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + 2-oxosuccinate
-
-
-
?
phenylpyruvate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + 2-oxoglutarate
-
-
-
?
phenylpyruvate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + 2-oxoglutarate
-
-
-
?
phenylpyruvate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + phenylpyruvate
-
-
-
?
phenylpyruvate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + phenylpyruvate
-
-
-
?
phenylpyruvate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
-
-
?
phenylpyruvate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
-
-
?
prephenate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + 2-oxosuccinate
-
-
-
?
prephenate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + 2-oxosuccinate
-
-
-
?
prephenate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + 2-oxoglutarate
-
-
-
?
prephenate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + 2-oxoglutarate
-
-
-
?
prephenate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + phenylpyruvate
-
-
-
?
prephenate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + phenylpyruvate
-
-
-
?
prephenate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + 4-hydroxyphenylpyruvate
-
-
-
?
prephenate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + 4-hydroxyphenylpyruvate
-
-
-
?
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
60
-
inactivated at, aromatic aminotransferase AT-1 loses activity much more precipitously than does aromatic aminotransferase AT-2
Pseudomonas aeruginosa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.2
-
L-glutamate, aromatic aminotransferase AT-1
Pseudomonas aeruginosa
7
-
L-Phe, L-Tyr, L-Asp or L-Glu as substrate, aromatic aminotransferase AT-2
Pseudomonas aeruginosa
7.6
-
L-Asp, aromatic aminotransferase AT-1
Pseudomonas aeruginosa
8.4
-
L-Phe or L-Tyr, aromatic aminotransferase AT-1
Pseudomonas aeruginosa
General Stability (protein specific)
General Stability
Organism
aromatic aminotransferase AT-1 is unstable to freeze-thaw treatment. With a single freeze-thaw cycle the enzyme loses about 50% of its original activity. Additional freeze-thaw treatments completely inactivate AT-1
Pseudomonas aeruginosa
aromatic aminotransferase AT-2 is stable to repeated freeze-thaw treatments
Pseudomonas aeruginosa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
64000
-
aromatic aminotransferase AT-1, gel filtration; aromatic aminotransferase AT-2, gel filtration
Pseudomonas aeruginosa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Pseudomonas aeruginosa
role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis
?
-
-
-
additional information
Pseudomonas aeruginosa
the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis
?
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxoglutarate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
L-glutamate + 2-oxosuccinic acid
-
-
-
?
2-oxoglutarate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
L-glutamate + 2-oxosuccinic acid
-
-
-
?
2-oxoglutarate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Glu + 2-oxoglutarate
-
-
-
?
2-oxoglutarate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Glu + 2-oxoglutarate
-
-
-
?
2-oxoglutarate + L-Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
L-Glu + phenylpyruvate
-
-
-
?
2-oxoglutarate + L-Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
L-Glu + phenylpyruvate
-
-
-
?
2-oxoglutarate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
?
2-oxoglutarate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
L-glutamate + 4-hydroxyphenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Tyr + 2-oxosuccinate
-
-
-
?
4-hydroxyphenylpyruvate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Tyr + 2-oxosuccinate
-
-
-
?
4-hydroxyphenylpyruvate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Tyr + 2-oxoglutarate
-
-
-
?
4-hydroxyphenylpyruvate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Tyr + 2-oxoglutarate
-
-
-
?
4-hydroxyphenylpyruvate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
tyr + phenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
tyr + phenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Tyr + 4-hydroxyphenylpyruvate
-
-
-
?
4-hydroxyphenylpyruvate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Tyr + 4-hydroxyphenylpyruvate
-
-
-
?
additional information
role of enzyme AT-2 in L-Phe and L-Tyr biosynthesis
662080
Pseudomonas aeruginosa
?
-
-
-
-
additional information
the enzyme AT-1 must primarily be engaged in L-aspartate and L-glutamate synthesis
662080
Pseudomonas aeruginosa
?
-
-
-
-
oxaloacetate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + oxaloacetate
-
-
-
?
oxaloacetate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + oxaloacetate
-
-
-
?
oxaloacetate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + 2-oxoglutarate
-
-
-
?
oxaloacetate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + 2-oxoglutarate
-
-
-
?
oxaloacetate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + phenylpyruvate
-
-
-
?
oxaloacetate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + phenylpyruvate
-
-
-
?
oxaloacetate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Asp + 4-hydroxyphenylpyruvate
-
-
-
?
oxaloacetate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Asp + 4-hydroxyphenylpyruvate
-
-
-
?
phenylpyruvate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + 2-oxosuccinate
-
-
-
?
phenylpyruvate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + 2-oxosuccinate
-
-
-
?
phenylpyruvate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + 2-oxoglutarate
-
-
-
?
phenylpyruvate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + 2-oxoglutarate
-
-
-
?
phenylpyruvate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + phenylpyruvate
-
-
-
?
phenylpyruvate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + phenylpyruvate
-
-
-
?
phenylpyruvate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
-
-
?
phenylpyruvate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
Phe + 3-(4-hydroxyphenyl)-2-oxopropanoic acid
-
-
-
?
prephenate + Asp
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + 2-oxosuccinate
-
-
-
?
prephenate + Asp
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + 2-oxosuccinate
-
-
-
?
prephenate + Glu
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + 2-oxoglutarate
-
-
-
?
prephenate + Glu
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + 2-oxoglutarate
-
-
-
?
prephenate + Phe
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + phenylpyruvate
-
-
-
?
prephenate + Phe
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + phenylpyruvate
-
-
-
?
prephenate + Tyr
aromatic aminotransferase AT-1
662080
Pseudomonas aeruginosa
arogenate + 4-hydroxyphenylpyruvate
-
-
-
?
prephenate + Tyr
aromatic aminotransferase AT-2
662080
Pseudomonas aeruginosa
arogenate + 4-hydroxyphenylpyruvate
-
-
-
?
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
60
-
inactivated at, aromatic aminotransferase AT-1 loses activity much more precipitously than does aromatic aminotransferase AT-2
Pseudomonas aeruginosa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.2
-
L-glutamate, aromatic aminotransferase AT-1
Pseudomonas aeruginosa
7
-
L-Phe, L-Tyr, L-Asp or L-Glu as substrate, aromatic aminotransferase AT-2
Pseudomonas aeruginosa
7.6
-
L-Asp, aromatic aminotransferase AT-1
Pseudomonas aeruginosa
8.4
-
L-Phe or L-Tyr, aromatic aminotransferase AT-1
Pseudomonas aeruginosa
Other publictions for EC 2.6.1.57
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737334
Rzad
Characterization of two aminot ...
Candida albicans, Candida albicans ATCC MYA-2876
Acta Biochim. Pol.
62
903-912
2015
-
-
1
-
-
-
-
12
-
-
6
-
-
4
-
-
-
-
-
-
-
-
22
2
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
12
-
-
7
-
-
-
-
-
-
-
-
-
22
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
738333
Pieck
Auxin and tryptophan homeostas ...
Arabidopsis thaliana
Genetics
201
185-199
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
739763
Romagnoli
Deletion of the Saccharomyces ...
Saccharomyces cerevisiae
Yeast
32
29-45
2015
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737425
Szkop
TyrB-2 and phhC genes of Pseud ...
Pseudomonas putida
Amino Acids
45
351-358
2013
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
10
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738949
Kulkarni
Indole-3-acetic acid biosynthe ...
Pantoea dispersa, Pantoea dispersa GPK
Lett. Appl. Microbiol.
56
340-347
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723053
Hirata
Functional characterization of ...
Rosa hybrid cultivar
J. Plant Physiol.
169
444-451
2012
-
-
1
-
-
-
1
-
-
-
1
-
-
2
-
-
-
-
-
6
-
-
4
1
1
-
-
-
1
-
-
1
-
1
-
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
6
-
-
4
1
1
-
-
-
1
-
-
1
-
1
1
-
-
-
723490
Castro-Guerrero
-
The hisC1 gene, encoding aroma ...
Azospirillum brasilense, Azospirillum brasilense Sp7
Plant Soil
356
139-150
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
710489
Chen
Crystallization and preliminar ...
Saccharomyces cerevisiae
Protein Pept. Lett.
16
450-453
2009
-
-
-
1
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689666
Sergeeva
-
Production of indole-3-acetic ...
Pantoea agglomerans
Plant Soil
297
1-13
2007
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672710
Cho
Engineering aromatic L-amino a ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
94
842-850
2006
-
-
1
-
4
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672719
Cho
-
Asymmetric synthesis of unnatu ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) T30
Biotechnol. Bioprocess Eng.
11
299-305
2006
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
1
1
4
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
1
4
-
-
-
-
-
-
-
-
-
-
-
677173
Fadnavis
-
Asymmetric synthesis of nonpro ...
Enterobacter sp., Enterobacter sp. BK2K-1
Tetrahedron
17
2199-2202
2006
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661783
Pedraza
Aromatic amino acid aminotrans ...
Azospirillum brasilense, Gluconacetobacter diazotrophicus, Pseudomonas stutzeri, Pseudomonas stutzeri A15
FEMS Microbiol. Lett.
233
15-21
2004
-
-
-
-
-
-
-
-
-
-
5
-
-
9
-
-
-
-
-
-
-
-
16
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
16
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636676
Cho
Asymmetric synthesis of L-homo ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
83
226-234
2003
-
-
1
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660743
Chambellon
CodY-regulated aminotransferas ...
Lactococcus lactis
Appl. Environ. Microbiol.
69
3061-3068
2003
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661888
Rijnen
-
Lactococcal aminotransferases ...
Lactococcus lactis
Int. Dairy J.
13
805-812
2003
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636675
Ward
Molecular analysis of the role ...
Pyrococcus furiosus
Archaea
1
133-141
2002
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745230
Ura
Temperature dependence of the ...
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
J. Biochem.
129
173-178
2001
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636673
Islam
The substrate activation proce ...
Escherichia coli
Biochemistry
39
15418-15428
2000
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636674
Matsui
The molecular structure of hyp ...
Pyrococcus horikoshii
J. Biol. Chem.
275
4871-4879
2000
-
-
1
1
-
-
-
-
-
-
2
-
-
4
-
-
1
-
-
-
-
-
3
1
1
-
2
-
-
-
1
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
3
1
1
-
2
-
-
-
1
-
-
-
-
-
-
-
636671
Okamoto
The active site of Paracoccus ...
Paracoccus denitrificans
Biochemistry
38
1176-1184
1999
-
-
-
1
-
-
21
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636672
Rijnen
Genetic characterization of th ...
Lactococcus lactis
Appl. Environ. Microbiol.
65
4873-4880
1999
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
491602
Iraqui
Characterisation of Saccharomy ...
Saccharomyces cerevisiae
Mol. Gen. Genet.
257
238-248
1998
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636668
Gao
-
Purification and characterizat ...
Lactococcus lactis
J. Food Biochem.
22
197-211
1998
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
5
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
5
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636669
Okamoto
Crystal structures of Paracocc ...
Paracoccus denitrificans
J. Mol. Biol.
280
443-461
1998
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636666
Simpson
-
Partial purification and chara ...
Vigna radiata
Planta
201
71-77
1997
-
-
-
-
-
-
1
5
-
-
1
-
-
1
-
-
1
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
5
-
-
1
-
-
-
-
1
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636667
Oue
Paracoccus denitrificans aroma ...
Paracoccus denitrificans
J. Biochem.
121
161-171
1997
-
-
1
-
-
-
-
6
-
-
3
-
-
3
-
-
1
-
-
-
-
-
6
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
6
-
-
3
-
-
-
-
1
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636663
Hayashi
Analysis of the substrate-reco ...
Escherichia coli
Biochemistry
35
6754-6761
1996
-
-
-
-
3
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
636664
Berger
Aromatic amino acid transamina ...
Crithidia fasciculata, Mus musculus, Trypanosoma brucei
Proc. Natl. Acad. Sci. USA
93
4126-4130
1996
-
-
-
-
-
-
-
8
-
-
-
6
-
3
-
-
-
-
-
1
-
-
29
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
8
-
-
-
6
-
-
-
-
-
1
-
-
29
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636665
Soto-Urzua
Purification and properties of ...
Azospirillum brasilense
Can. J. Microbiol.
42
294-298
1996
-
-
-
-
-
1
1
8
-
-
2
-
-
2
-
-
1
-
-
-
1
-
6
1
-
-
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
8
-
-
2
-
-
-
-
1
-
-
1
-
6
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
721696
Andreotti
An extremely thermostable arom ...
Pyrococcus furiosus
Biochim. Biophys. Acta
1247
90-96
1995
-
-
-
-
-
-
-
4
-
-
2
-
-
5
1
-
1
-
-
-
-
-
3
1
1
-
3
4
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
2
-
-
1
-
1
-
-
-
-
3
1
1
-
3
4
-
-
-
-
-
-
-
-
-
-
636648
Andreotti
Characterization of aromatic a ...
Methanococcus aeolicus, Pyrococcus furiosus, Thermococcus litoralis
Eur. J. Biochem.
220
543-549
1994
-
-
-
-
-
-
-
13
-
-
6
2
-
3
-
-
2
1
-
-
3
-
11
2
2
2
2
4
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
13
-
-
6
2
-
-
-
2
-
-
3
-
11
2
2
2
2
4
-
-
-
-
-
-
-
-
-
-
636661
Iwasaki
Protonation state of the activ ...
Escherichia coli
J. Biochem.
115
156-161
1994
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636651
Hayashi
Escherichia coli aromatic amin ...
Escherichia coli
Biochemistry
32
12229-12239
1993
-
-
1
-
-
-
-
9
-
-
3
-
-
2
-
-
-
-
-
-
1
-
4
1
-
-
-
4
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
9
-
-
3
-
-
-
-
-
-
-
1
-
4
1
-
-
-
4
-
-
-
-
-
-
-
-
-
-
636644
Perez-Galdona
Characterization of an aromati ...
Rhizobium leguminosarum
Biochimie
74
539-544
1992
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
6
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
636645
Mavrides
Transamination of aromatic ami ...
Escherichia coli
Methods Enzymol.
142
253-267
1987
-
-
-
-
-
1
-
5
-
-
1
-
-
1
-
-
1
-
-
-
1
1
10
-
-
-
1
5
2
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
5
-
-
1
-
-
-
-
1
-
-
1
1
10
-
-
-
1
5
2
-
-
-
-
-
-
-
-
-
636646
Noguchi
Aromatic-amino-acid aminotrans ...
Rattus norvegicus
Methods Enzymol.
142
267-273
1987
-
-
-
-
-
-
-
4
1
-
2
-
-
1
-
-
1
-
-
1
1
2
4
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
1
-
2
-
-
-
-
1
-
1
1
2
4
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
636650
Kanda
Purification and properties of ...
Brevibacillus brevis
J. Biochem.
101
871-878
1987
-
-
-
-
-
-
-
8
-
-
2
-
-
2
-
-
1
-
-
-
1
1
8
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
8
-
-
2
-
-
-
-
1
-
-
1
1
8
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
636649
Lee
-
Partial purification and some ...
Brevibacterium linens, Brevibacterium linens 47
J. Gen. Microbiol.
131
459-467
1985
-
-
-
-
-
-
-
4
-
-
1
2
-
3
-
-
1
-
-
-
4
1
13
-
1
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
1
2
-
-
-
1
-
-
4
1
13
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
636652
Kuramitsu
Aromatic amino acid aminotrans ...
Escherichia coli
Biochem. Biophys. Res. Commun.
133
134-139
1985
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636657
Bode
-
Charakterisierung von drei aro ...
Candida maltosa
Z. Allg. Mikrobiol.
24
67-75
1984
-
-
-
-
-
-
4
16
-
-
3
-
-
1
-
-
1
-
-
-
-
-
15
-
-
-
-
-
-
-
-
1
9
-
-
-
-
-
1
-
-
-
-
4
9
16
-
-
3
-
-
-
-
1
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636655
Beschle
Properties of aromatic-amino-a ...
Flavobacterium sp.
Hoppe-Seyler's Z. Physiol. Chem.
363
1365-1375
1982
-
-
-
-
-
1
4
8
-
-
1
-
-
1
-
-
1
1
-
-
2
-
8
-
2
-
2
-
2
2
-
1
-
-
-
-
-
-
1
-
-
1
-
4
-
8
-
-
1
-
-
-
-
1
-
-
2
-
8
-
2
-
2
-
2
2
-
-
-
-
-
-
-
-
662080
Whitaker
A multispecific quintet of aro ...
Pseudomonas aeruginosa
J. Biol. Chem.
257
13550-13556
1982
-
-
-
-
-
2
-
-
-
-
1
2
-
2
-
-
-
-
-
-
-
-
42
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
42
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
636654
Paris
Purification and properties of ...
Klebsiella aerogenes
J. Bacteriol.
145
266-271
1981
-
-
-
-
-
-
1
6
-
-
2
-
-
3
-
-
1
-
-
-
-
1
3
1
-
-
1
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
6
-
-
2
-
-
-
-
1
-
-
-
1
3
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
636653
Fazel
Aromatic aminotransferases in ...
Brevibacterium flavum, Corynebacterium ammoniagenes, Corynebacterium glutamicum
J. Bacteriol.
140
580-587
1979
-
-
-
-
-
-
3
-
-
-
5
-
-
6
-
-
3
-
-
-
-
-
15
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
5
-
-
-
-
3
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636647
Powell
The purification and propertie ...
Escherichia coli
Eur. J. Biochem.
87
391-400
1978
-
-
-
-
-
1
-
12
-
-
2
-
-
2
-
-
1
1
-
-
-
-
6
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
12
-
-
2
-
-
-
-
1
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
636658
Mavrides
Aminotransferases for aromatic ...
Bacillus subtilis
Biochim. Biophys. Acta
524
60-67
1978
-
-
-
-
-
-
-
7
-
-
2
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
2
-
-
-
-
1
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
636659
Weigent
Purification and properties of ...
Bacillus subtilis
J. Biol. Chem.
251
6974-6980
1976
-
-
-
-
-
2
-
4
-
-
1
-
-
2
-
-
1
1
-
-
2
1
2
-
-
-
2
-
1
-
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
4
-
-
1
-
-
-
-
1
-
-
2
1
2
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
636643
Mavrides
Multispecific aspartate and ar ...
Escherichia coli
J. Biol. Chem.
250
4128-4133
1975
-
-
-
-
-
-
-
5
-
-
1
-
-
2
-
-
1
-
-
-
-
-
3
1
1
-
1
-
2
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
1
-
-
-
-
1
-
-
-
-
3
1
1
-
1
-
2
2
-
-
-
-
-
-
-
-
636660
Xing
Characterization of amino acid ...
Methanococcus aeolicus
J. Bacteriol.
174
541-548
1974
-
-
-
-
-
-
3
11
-
-
2
3
-
4
-
-
1
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
11
-
-
2
3
-
-
-
1
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
636656
Nakamura
Aromatic amino acid transamina ...
Rattus norvegicus
Biochem. J.
135
815-818
1973
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-