BRENDA - Enzyme Database show
show all sequences of 2.6.1.57

Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism

Oue, S.; Okamoto, A.; Nakai, Y.; Nakahira, M.; Shibatani, T.; Hayashi, H.; Kagamiyama, H.; J. Biochem. 121, 161-171 (1997)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Paracoccus denitrificans
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.059
-
3-(4-hydroxyphenyl)pyruvate
pH 8.0, 25°C, cosubstrate aspartate
Paracoccus denitrificans
0.083
-
phenylpyruvate
pH 8.0, 25°C, cosubstrate aspartate
Paracoccus denitrificans
0.14
-
2-oxoglutarate
pH 8.0, 25°C, cosubstrate tryptophan
Paracoccus denitrificans
0.59
-
2-oxoglutarate
pH 8.0, 25°C, cosubstrate aspartate
Paracoccus denitrificans
1.4
-
L-tryptophan
pH 8.0, 25°C, cosubstrate 2-oxoglutarate
Paracoccus denitrificans
1.8
-
L-aspartate
pH 8.0, 25°C, cosubstrate 2-oxoglutarate
Paracoccus denitrificans
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42653
-
2 * 42653, mass spectrometry
Paracoccus denitrificans
42731
-
2 * 42731, deduced from nucleotide sequence
Paracoccus denitrificans
83000
-
gel filtration
Paracoccus denitrificans
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Paracoccus denitrificans
P95468
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate, phenyl-Toyopearl, hydroxyapatite, Sephacryl S-200, recombinant enzyme
Paracoccus denitrificans
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
aspartate + 3-phenylpyruvate
-
636667
Paracoccus denitrificans
oxaloacetate + L-phenylalanine
-
636667
Paracoccus denitrificans
r
L-aspartate + 2-oxoglutarate
-
636667
Paracoccus denitrificans
oxaloacetate + L-glutamate
-
636667
Paracoccus denitrificans
r
L-aspartate + 3-(4-hydroxyphenyl)pyruvate
-
636667
Paracoccus denitrificans
L-tyrosine + oxaloacetate
-
636667
Paracoccus denitrificans
r
L-phenylalanine + 2-oxoglutarate
enzyme also reacts with 2-aminooctanoate and 2-aminoheptanoate
636667
Paracoccus denitrificans
phenylpyruvate + L-glutamate
-
636667
Paracoccus denitrificans
r
L-tryptophan + 2-oxoglutarate
-
636667
Paracoccus denitrificans
3-indole-2-oxopropanoate + L-glutamate
-
636667
Paracoccus denitrificans
r
L-tyrosine + 2-oxoglutarate
-
636667
Paracoccus denitrificans
p-hydroxyphenylpyruvate + L-glutamate
-
636667
Paracoccus denitrificans
r
Subunits
Subunits
Commentary
Organism
dimer
2 * 42653, mass spectrometry; 2 * 42731, deduced from nucleotide sequence
Paracoccus denitrificans
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
1 pyridoxal 5'-phosphate per subunit
Paracoccus denitrificans
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Paracoccus denitrificans
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
1 pyridoxal 5'-phosphate per subunit
Paracoccus denitrificans
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.059
-
3-(4-hydroxyphenyl)pyruvate
pH 8.0, 25°C, cosubstrate aspartate
Paracoccus denitrificans
0.083
-
phenylpyruvate
pH 8.0, 25°C, cosubstrate aspartate
Paracoccus denitrificans
0.14
-
2-oxoglutarate
pH 8.0, 25°C, cosubstrate tryptophan
Paracoccus denitrificans
0.59
-
2-oxoglutarate
pH 8.0, 25°C, cosubstrate aspartate
Paracoccus denitrificans
1.4
-
L-tryptophan
pH 8.0, 25°C, cosubstrate 2-oxoglutarate
Paracoccus denitrificans
1.8
-
L-aspartate
pH 8.0, 25°C, cosubstrate 2-oxoglutarate
Paracoccus denitrificans
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42653
-
2 * 42653, mass spectrometry
Paracoccus denitrificans
42731
-
2 * 42731, deduced from nucleotide sequence
Paracoccus denitrificans
83000
-
gel filtration
Paracoccus denitrificans
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate, phenyl-Toyopearl, hydroxyapatite, Sephacryl S-200, recombinant enzyme
Paracoccus denitrificans
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
aspartate + 3-phenylpyruvate
-
636667
Paracoccus denitrificans
oxaloacetate + L-phenylalanine
-
636667
Paracoccus denitrificans
r
L-aspartate + 2-oxoglutarate
-
636667
Paracoccus denitrificans
oxaloacetate + L-glutamate
-
636667
Paracoccus denitrificans
r
L-aspartate + 3-(4-hydroxyphenyl)pyruvate
-
636667
Paracoccus denitrificans
L-tyrosine + oxaloacetate
-
636667
Paracoccus denitrificans
r
L-phenylalanine + 2-oxoglutarate
enzyme also reacts with 2-aminooctanoate and 2-aminoheptanoate
636667
Paracoccus denitrificans
phenylpyruvate + L-glutamate
-
636667
Paracoccus denitrificans
r
L-tryptophan + 2-oxoglutarate
-
636667
Paracoccus denitrificans
3-indole-2-oxopropanoate + L-glutamate
-
636667
Paracoccus denitrificans
r
L-tyrosine + 2-oxoglutarate
-
636667
Paracoccus denitrificans
p-hydroxyphenylpyruvate + L-glutamate
-
636667
Paracoccus denitrificans
r
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 42653, mass spectrometry; 2 * 42731, deduced from nucleotide sequence
Paracoccus denitrificans
Other publictions for EC 2.6.1.57
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737334
Rzad
Characterization of two aminot ...
Candida albicans, Candida albicans ATCC MYA-2876
Acta Biochim. Pol.
62
903-912
2015
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1
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-
12
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6
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4
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22
2
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1
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2
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12
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7
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22
3
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2
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738333
Pieck
Auxin and tryptophan homeostas ...
Arabidopsis thaliana
Genetics
201
185-199
2015
-
-
-
-
-
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-
-
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3
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1
1
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739763
Romagnoli
Deletion of the Saccharomyces ...
Saccharomyces cerevisiae
Yeast
32
29-45
2015
-
1
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4
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1
1
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737425
Szkop
TyrB-2 and phhC genes of Pseud ...
Pseudomonas putida
Amino Acids
45
351-358
2013
-
-
-
-
-
-
-
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-
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2
-
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2
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10
1
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2
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10
2
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-
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738949
Kulkarni
Indole-3-acetic acid biosynthe ...
Pantoea dispersa, Pantoea dispersa GPK
Lett. Appl. Microbiol.
56
340-347
2013
-
-
-
-
-
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-
-
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6
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8
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8
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723053
Hirata
Functional characterization of ...
Rosa hybrid cultivar
J. Plant Physiol.
169
444-451
2012
-
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1
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1
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1
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2
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6
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4
1
1
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1
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1
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1
1
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1
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1
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6
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4
1
1
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1
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1
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1
1
-
-
-
723490
Castro-Guerrero
-
The hisC1 gene, encoding aroma ...
Azospirillum brasilense, Azospirillum brasilense Sp7
Plant Soil
356
139-150
2012
-
-
-
-
-
-
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-
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2
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1
1
1
1
-
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710489
Chen
Crystallization and preliminar ...
Saccharomyces cerevisiae
Protein Pept. Lett.
16
450-453
2009
-
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1
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1
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3
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1
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689666
Sergeeva
-
Production of indole-3-acetic ...
Pantoea agglomerans
Plant Soil
297
1-13
2007
-
-
-
-
-
-
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1
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1
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1
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672710
Cho
Engineering aromatic L-amino a ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
94
842-850
2006
-
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1
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4
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5
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1
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8
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1
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4
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1
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8
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672719
Cho
-
Asymmetric synthesis of unnatu ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) T30
Biotechnol. Bioprocess Eng.
11
299-305
2006
-
1
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2
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4
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1
1
4
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677173
Fadnavis
-
Asymmetric synthesis of nonpro ...
Enterobacter sp., Enterobacter sp. BK2K-1
Tetrahedron
17
2199-2202
2006
-
1
1
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4
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4
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1
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4
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661783
Pedraza
Aromatic amino acid aminotrans ...
Azospirillum brasilense, Gluconacetobacter diazotrophicus, Pseudomonas stutzeri, Pseudomonas stutzeri A15
FEMS Microbiol. Lett.
233
15-21
2004
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5
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9
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16
2
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5
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16
2
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636676
Cho
Asymmetric synthesis of L-homo ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
83
226-234
2003
-
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1
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7
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2
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660743
Chambellon
CodY-regulated aminotransferas ...
Lactococcus lactis
Appl. Environ. Microbiol.
69
3061-3068
2003
-
-
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1
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661888
Rijnen
-
Lactococcal aminotransferases ...
Lactococcus lactis
Int. Dairy J.
13
805-812
2003
1
-
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1
-
-
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1
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636675
Ward
Molecular analysis of the role ...
Pyrococcus furiosus
Archaea
1
133-141
2002
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1
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1
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3
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1
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1
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2
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745230
Ura
Temperature dependence of the ...
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
J. Biochem.
129
173-178
2001
-
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1
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2
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636673
Islam
The substrate activation proce ...
Escherichia coli
Biochemistry
39
15418-15428
2000
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1
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3
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2
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1
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Paracoccus denitrificans aroma ...
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Analysis of the substrate-reco ...
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Aromatic amino acid transamina ...
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Transamination of aromatic ami ...
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1974
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11
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636656
Nakamura
Aromatic amino acid transamina ...
Rattus norvegicus
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135
815-818
1973
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