BRENDA - Enzyme Database show
show all sequences of 2.6.1.57

Charakterisierung von drei aromatischen Aminotransferasen aus Candida maltosa

Bode, R.; Birnbaum, D.; Z. Allg. Mikrobiol. 24, 67-75 (1984)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
4-hydroxyphenylpyruvate
substrate inhibition
Candida maltosa
Indole pyruvate
substrate inhibition
Candida maltosa
phenylpyruvate
substrate inhibition
Candida maltosa
prephenate
substrate inhibition
Candida maltosa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Km values of AAT I and II are very similar for a variety of substrates, Km values for AAT II are higher
Candida maltosa
0.001
-
pyridoxal 5'-phosphate
pH 8.6, 37C, AAT I
Candida maltosa
0.05
-
4-hydroxyphenylpyruvate
pH 8.6, 37C, AAT I
Candida maltosa
0.06
-
Indolepyruvate
pH 8.6, 37C, AAT I
Candida maltosa
0.08
-
phenylpyruvate
pH 8.6, 37C, AAT I
Candida maltosa
0.08
-
prephenate
pH 8.6, 37C, AAT I
Candida maltosa
0.4
-
L-tyrosine
pH 8.6, 37C, AAT I
Candida maltosa
0.44
-
L-phenylalanine
pH 8.6, 37C, AAT I
Candida maltosa
0.45
-
L-arogenate
pH 8.6, 37C, AAT I
Candida maltosa
2.5
-
L-tryptophan
pH 8.6, 37C, AAT I
Candida maltosa
3.3
-
oxaloacetate
pH 8.6, 37C, AAT I
Candida maltosa
4
-
L-leucine
pH 8.6, 37C, AAT I
Candida maltosa
5
-
2-oxoglutarate
pH 8.6, 37C, AAT I
Candida maltosa
5
-
L-histidine
pH 8.6, 37C, AAT I
Candida maltosa
5
-
L-methionine
pH 8.6, 37C, AAT I
Candida maltosa
7
-
L-glutamine
pH 8.6, 37C, AAT I
Candida maltosa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
73000
-
isoenzyme AAT-I, gel filtration
Candida maltosa
85000
-
isoenzyme AAT-II, gel filtration
Candida maltosa
105000
-
isoenzyme AAT-III, gel filtration
Candida maltosa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Candida maltosa
-
-
-
Purification (Commentary)
Commentary
Organism
DEAE-cellulose, isolation of isoenzymes AAT I, AAT II and AAT III
Candida maltosa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-arogenate + indolepyruvate
-
636657
Candida maltosa
L-tryptophan + 3-(1-carboxy-4-hydroxycyclohexa-2,5-dienyl)2-oxopropanoate
-
636657
Candida maltosa
?
L-glutamine + indole pyruvate
AAT I and II
636657
Candida maltosa
2-oxoglutamine + L-tryptophan
-
636657
Candida maltosa
?
L-histidine + indole pyruvate
-
636657
Candida maltosa
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-tryptophan
-
636657
Candida maltosa
?
L-leucine + indole pyruvate
-
636657
Candida maltosa
4-methyl-2-oxopentanoate + L-tryptophan
-
636657
Candida maltosa
?
L-methionine + indole pyruvate
AAT I and II
636657
Candida maltosa
4-methylsulfanyl-2-oxobutanoate + L-tryptophan
-
636657
Candida maltosa
?
L-phenylalanine + 2-oxoglutarate
completely inactive with D-isomers of aromatic amino acids
636657
Candida maltosa
phenylpyruvate + L-glutamate
-
636657
Candida maltosa
?
L-phenylalanine + 2-oxoglutarate
specificities of isoenzymes: AAT I, AAT II, AAT III
636657
Candida maltosa
phenylpyruvate + L-glutamate
-
636657
Candida maltosa
?
L-tryptophan + 2-oxoglutarate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-glutamate
-
636657
Candida maltosa
?
L-tryptophan + indole pyruvate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-tryptophan
-
636657
Candida maltosa
?
L-tryptophan + oxaloacetate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-aspartate
-
636657
Candida maltosa
?
L-tryptophan + phenylpyruvate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-phenylalanine
-
636657
Candida maltosa
?
L-tyrosine + 2-oxoglutarate
-
636657
Candida maltosa
p-hydroxyphenylpyruvate + L-glutamate
-
636657
Candida maltosa
?
L-tyrosine + indole pyruvate
-
636657
Candida maltosa
4-hydroxyphenylpyruvate + L-tryptophan
-
636657
Candida maltosa
?
prephenate + L-glutamate
-
636657
Candida maltosa
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate
-
636657
Candida maltosa
?
prephenate + L-tryptophan
-
636657
Candida maltosa
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 3-indole-2-oxopropanoate
-
636657
Candida maltosa
?
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
a pyridoxal phosphate protein; Km: 0.001 mM, isoenzyme AAT I, 0.0005 mM, isoenzyme AAT II, AAT III
Candida maltosa
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.3
-
4-hydroxyphenylpyruvate
AAT III, substrate inhibition
Candida maltosa
0.3
-
indolpyruvate
AAT I and III, substrate inhibition; AAT I, substrate inhibition
Candida maltosa
0.4
-
4-hydroxyphenylpyruvate
AAT I, substrate inhibition
Candida maltosa
0.4
-
prephenate
AAT I and III, substrate inhibition; AAT I, substrate inhibition
Candida maltosa
0.5
-
phenylpyruvate
AAT III, substrate inhibition; AAT I, substrate inhibition
Candida maltosa
1.5
-
indolpyruvate
AAT II, substrate inhibition
Candida maltosa
10
-
4-hydroxyphenylpyruvate
AAT II, substrate inhibition
Candida maltosa
15
-
phenylpyruvate
AAT II, substrate inhibition
Candida maltosa
15
-
prephenate
AAT II, substrate inhibition
Candida maltosa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
a pyridoxal phosphate protein; Km: 0.001 mM, isoenzyme AAT I, 0.0005 mM, isoenzyme AAT II, AAT III
Candida maltosa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-hydroxyphenylpyruvate
substrate inhibition
Candida maltosa
Indole pyruvate
substrate inhibition
Candida maltosa
phenylpyruvate
substrate inhibition
Candida maltosa
prephenate
substrate inhibition
Candida maltosa
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.3
-
4-hydroxyphenylpyruvate
AAT III, substrate inhibition
Candida maltosa
0.3
-
indolpyruvate
AAT I and III, substrate inhibition; AAT I, substrate inhibition
Candida maltosa
0.4
-
4-hydroxyphenylpyruvate
AAT I, substrate inhibition
Candida maltosa
0.4
-
prephenate
AAT I and III, substrate inhibition; AAT I, substrate inhibition
Candida maltosa
0.5
-
phenylpyruvate
AAT III, substrate inhibition; AAT I, substrate inhibition
Candida maltosa
1.5
-
indolpyruvate
AAT II, substrate inhibition
Candida maltosa
10
-
4-hydroxyphenylpyruvate
AAT II, substrate inhibition
Candida maltosa
15
-
phenylpyruvate
AAT II, substrate inhibition
Candida maltosa
15
-
prephenate
AAT II, substrate inhibition
Candida maltosa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Km values of AAT I and II are very similar for a variety of substrates, Km values for AAT II are higher
Candida maltosa
0.001
-
pyridoxal 5'-phosphate
pH 8.6, 37C, AAT I
Candida maltosa
0.05
-
4-hydroxyphenylpyruvate
pH 8.6, 37C, AAT I
Candida maltosa
0.06
-
Indolepyruvate
pH 8.6, 37C, AAT I
Candida maltosa
0.08
-
phenylpyruvate
pH 8.6, 37C, AAT I
Candida maltosa
0.08
-
prephenate
pH 8.6, 37C, AAT I
Candida maltosa
0.4
-
L-tyrosine
pH 8.6, 37C, AAT I
Candida maltosa
0.44
-
L-phenylalanine
pH 8.6, 37C, AAT I
Candida maltosa
0.45
-
L-arogenate
pH 8.6, 37C, AAT I
Candida maltosa
2.5
-
L-tryptophan
pH 8.6, 37C, AAT I
Candida maltosa
3.3
-
oxaloacetate
pH 8.6, 37C, AAT I
Candida maltosa
4
-
L-leucine
pH 8.6, 37C, AAT I
Candida maltosa
5
-
2-oxoglutarate
pH 8.6, 37C, AAT I
Candida maltosa
5
-
L-histidine
pH 8.6, 37C, AAT I
Candida maltosa
5
-
L-methionine
pH 8.6, 37C, AAT I
Candida maltosa
7
-
L-glutamine
pH 8.6, 37C, AAT I
Candida maltosa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
73000
-
isoenzyme AAT-I, gel filtration
Candida maltosa
85000
-
isoenzyme AAT-II, gel filtration
Candida maltosa
105000
-
isoenzyme AAT-III, gel filtration
Candida maltosa
Purification (Commentary) (protein specific)
Commentary
Organism
DEAE-cellulose, isolation of isoenzymes AAT I, AAT II and AAT III
Candida maltosa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-arogenate + indolepyruvate
-
636657
Candida maltosa
L-tryptophan + 3-(1-carboxy-4-hydroxycyclohexa-2,5-dienyl)2-oxopropanoate
-
636657
Candida maltosa
?
L-glutamine + indole pyruvate
AAT I and II
636657
Candida maltosa
2-oxoglutamine + L-tryptophan
-
636657
Candida maltosa
?
L-histidine + indole pyruvate
-
636657
Candida maltosa
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-tryptophan
-
636657
Candida maltosa
?
L-leucine + indole pyruvate
-
636657
Candida maltosa
4-methyl-2-oxopentanoate + L-tryptophan
-
636657
Candida maltosa
?
L-methionine + indole pyruvate
AAT I and II
636657
Candida maltosa
4-methylsulfanyl-2-oxobutanoate + L-tryptophan
-
636657
Candida maltosa
?
L-phenylalanine + 2-oxoglutarate
completely inactive with D-isomers of aromatic amino acids
636657
Candida maltosa
phenylpyruvate + L-glutamate
-
636657
Candida maltosa
?
L-phenylalanine + 2-oxoglutarate
specificities of isoenzymes: AAT I, AAT II, AAT III
636657
Candida maltosa
phenylpyruvate + L-glutamate
-
636657
Candida maltosa
?
L-tryptophan + 2-oxoglutarate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-glutamate
-
636657
Candida maltosa
?
L-tryptophan + indole pyruvate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-tryptophan
-
636657
Candida maltosa
?
L-tryptophan + oxaloacetate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-aspartate
-
636657
Candida maltosa
?
L-tryptophan + phenylpyruvate
-
636657
Candida maltosa
3-indole-2-oxopropanoate + L-phenylalanine
-
636657
Candida maltosa
?
L-tyrosine + 2-oxoglutarate
-
636657
Candida maltosa
p-hydroxyphenylpyruvate + L-glutamate
-
636657
Candida maltosa
?
L-tyrosine + indole pyruvate
-
636657
Candida maltosa
4-hydroxyphenylpyruvate + L-tryptophan
-
636657
Candida maltosa
?
prephenate + L-glutamate
-
636657
Candida maltosa
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate
-
636657
Candida maltosa
?
prephenate + L-tryptophan
-
636657
Candida maltosa
1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 3-indole-2-oxopropanoate
-
636657
Candida maltosa
?
Other publictions for EC 2.6.1.57
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737334
Rzad
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22
2
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1
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2
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12
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7
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22
3
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Auxin and tryptophan homeostas ...
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3
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1
1
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4
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1
1
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737425
Szkop
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Amino Acids
45
351-358
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-
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2
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2
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1
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10
2
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738949
Kulkarni
Indole-3-acetic acid biosynthe ...
Pantoea dispersa, Pantoea dispersa GPK
Lett. Appl. Microbiol.
56
340-347
2013
-
-
-
-
-
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6
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8
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723053
Hirata
Functional characterization of ...
Rosa hybrid cultivar
J. Plant Physiol.
169
444-451
2012
-
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1
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1
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1
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2
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6
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4
1
1
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1
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1
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1
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1
1
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1
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1
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6
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4
1
1
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1
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1
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1
1
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-
723490
Castro-Guerrero
-
The hisC1 gene, encoding aroma ...
Azospirillum brasilense, Azospirillum brasilense Sp7
Plant Soil
356
139-150
2012
-
-
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-
-
-
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2
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1
1
1
1
-
-
710489
Chen
Crystallization and preliminar ...
Saccharomyces cerevisiae
Protein Pept. Lett.
16
450-453
2009
-
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1
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1
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3
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1
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1
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1
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1
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689666
Sergeeva
-
Production of indole-3-acetic ...
Pantoea agglomerans
Plant Soil
297
1-13
2007
-
-
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1
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1
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1
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672710
Cho
Engineering aromatic L-amino a ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
94
842-850
2006
-
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1
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4
-
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5
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1
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8
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1
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4
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1
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8
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672719
Cho
-
Asymmetric synthesis of unnatu ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) T30
Biotechnol. Bioprocess Eng.
11
299-305
2006
-
1
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2
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1
4
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1
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Aromatic amino acid aminotrans ...
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CodY-regulated aminotransferas ...
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2003
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Molecular analysis of the role ...
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Temperature dependence of the ...
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Paracoccus denitrificans aroma ...
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Analysis of the substrate-reco ...
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An extremely thermostable arom ...
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Characterization of aromatic a ...
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Escherichia coli aromatic amin ...
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Transamination of aromatic ami ...
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-
-
1
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636655
Beschle
Properties of aromatic-amino-a ...
Flavobacterium sp.
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1365-1375
1982
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-
-
-
-
1
4
8
-
-
1
-
-
1
-
-
1
1
-
-
2
-
8
-
2
-
2
-
2
2
-
1
-
-
-
-
-
-
1
-
-
1
-
4
-
8
-
-
1
-
-
-
-
1
-
-
2
-
8
-
2
-
2
-
2
2
-
-
-
-
-
-
-
-
662080
Whitaker
A multispecific quintet of aro ...
Pseudomonas aeruginosa
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13550-13556
1982
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-
-
-
-
2
-
-
-
-
1
2
-
2
-
-
-
-
-
-
-
-
42
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
42
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
636654
Paris
Purification and properties of ...
Klebsiella aerogenes
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1981
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-
-
-
-
-
1
6
-
-
2
-
-
3
-
-
1
-
-
-
-
1
3
1
-
-
1
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
6
-
-
2
-
-
-
-
1
-
-
-
1
3
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
636653
Fazel
Aromatic aminotransferases in ...
Brevibacterium flavum, Corynebacterium ammoniagenes, Corynebacterium glutamicum
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580-587
1979
-
-
-
-
-
-
3
-
-
-
5
-
-
6
-
-
3
-
-
-
-
-
15
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
5
-
-
-
-
3
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636647
Powell
The purification and propertie ...
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1978
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-
-
-
-
1
-
12
-
-
2
-
-
2
-
-
1
1
-
-
-
-
6
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
12
-
-
2
-
-
-
-
1
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
636658
Mavrides
Aminotransferases for aromatic ...
Bacillus subtilis
Biochim. Biophys. Acta
524
60-67
1978
-
-
-
-
-
-
-
7
-
-
2
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
2
-
-
-
-
1
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
636659
Weigent
Purification and properties of ...
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6974-6980
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-
-
-
-
2
-
4
-
-
1
-
-
2
-
-
1
1
-
-
2
1
2
-
-
-
2
-
1
-
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
4
-
-
1
-
-
-
-
1
-
-
2
1
2
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
636643
Mavrides
Multispecific aspartate and ar ...
Escherichia coli
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4128-4133
1975
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-
-
-
-
-
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5
-
-
1
-
-
2
-
-
1
-
-
-
-
-
3
1
1
-
1
-
2
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
1
-
-
-
-
1
-
-
-
-
3
1
1
-
1
-
2
2
-
-
-
-
-
-
-
-
636660
Xing
Characterization of amino acid ...
Methanococcus aeolicus
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541-548
1974
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-
-
-
-
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3
11
-
-
2
3
-
4
-
-
1
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
11
-
-
2
3
-
-
-
1
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
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636656
Nakamura
Aromatic amino acid transamina ...
Rattus norvegicus
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815-818
1973
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-
-
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-
-
-
-
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-
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2
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1
-
-
2
-
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-
1
-
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-
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-
-
-
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-
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-
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-
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-
-
1
-
2
-
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-
1
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-