BRENDA - Enzyme Database show
show all sequences of 2.6.1.57

Partial purification and some properties of an aromatic-amino-acid and an aspartate aminotransferase in Brevibacterium linens 47

Lee, C.W.; Desmazeaud, M.J.; J. Gen. Microbiol. 131, 459-467 (1985)
No PubMed abstract available

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.7
-
L-tryptophan
pH 8.5, 37°C
Brevibacterium linens
1.3
-
L-phenylalanine
pH 8.5, 37°C
Brevibacterium linens
1.4
-
L-tyrosine
pH 8.5, 37°C
Brevibacterium linens
8.4
-
L-aspartate
pH 8.5, 37°C
Brevibacterium linens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
126000
-
gel filtration
Brevibacterium linens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-phenylalanine + 2-oxoglutarate
Brevibacterium linens
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
-
-
L-phenylalanine + 2-oxoglutarate
Brevibacterium linens 47
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Brevibacterium linens
-
-
-
Brevibacterium linens 47
-
-
-
Purification (Commentary)
Commentary
Organism
Streptomycin sulfate and ammonium sulfate, DEAE-Trisacryl, HA-ultrogel, Sephacryl S-200, partial purification
Brevibacterium linens
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.8
-
with tyrosine
Brevibacterium linens
2.96
-
with aspartate
Brevibacterium linens
3.8
-
with tryptophan
Brevibacterium linens
6.5
-
with phenylalanine
Brevibacterium linens
Storage Stability
Storage Stability
Organism
4°C, 100 mM potassium phosphate buffer, pH 7.5, 0.002% NaN3, at least 6 months, no loss of activity
Brevibacterium linens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
aspartate + 2-oxoglutarate
-
636649
Brevibacterium linens
oxaloacetate + L-glutamate
-
636649
Brevibacterium linens
?
L-methionine + 2-oxoglutarate
-
636649
Brevibacterium linens
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
636649
Brevibacterium linens
?
L-phenylalanine + 2-oxoglutarate
completely inactive with D-isomers of aromatic amino acids
636649
Brevibacterium linens
phenylpyruvate + L-glutamate
-
636649
Brevibacterium linens
?
L-phenylalanine + 2-oxoglutarate
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
636649
Brevibacterium linens
phenylpyruvate + L-glutamate
-
-
-
-
L-phenylalanine + 2-oxoglutarate
completely inactive with D-isomers of aromatic amino acids
636649
Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
636649
Brevibacterium linens 47
?
L-phenylalanine + 2-oxoglutarate
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
636649
Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
-
-
-
L-phenylalanine + oxaloacetate
-
636649
Brevibacterium linens
phenylpyruvate + L-aspartate
-
636649
Brevibacterium linens
?
L-phenylalanine + oxaloacetate
-
636649
Brevibacterium linens 47
phenylpyruvate + L-aspartate
-
636649
Brevibacterium linens 47
?
L-tryptophan + 2-oxoglutarate
-
636649
Brevibacterium linens
3-indole-2-oxopropanoate + L-glutamate
-
636649
Brevibacterium linens
?
L-tryptophan + 2-oxoglutarate
-
636649
Brevibacterium linens 47
3-indole-2-oxopropanoate + L-glutamate
-
636649
Brevibacterium linens 47
?
L-tryptophan + oxaloacetate
-
636649
Brevibacterium linens
3-indole-2-oxopropanoate + L-aspartate
-
636649
Brevibacterium linens
?
L-tyrosine + 2-oxoglutarate
-
636649
Brevibacterium linens
p-hydroxyphenylpyruvate + L-glutamate
-
636649
Brevibacterium linens
-
L-tyrosine + 2-oxoglutarate
-
636649
Brevibacterium linens 47
p-hydroxyphenylpyruvate + L-glutamate
-
636649
Brevibacterium linens 47
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
40
at pH 8.5
Brevibacterium linens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
9
phenylalanine
Brevibacterium linens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6.5
10
approx. 45% of maximal activity at pH 6.5, approx. 50% of maximal activity at pH 10
Brevibacterium linens
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
a pyridoxal phosphate protein; tightly bound to enzyme
Brevibacterium linens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
a pyridoxal phosphate protein; tightly bound to enzyme
Brevibacterium linens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.7
-
L-tryptophan
pH 8.5, 37°C
Brevibacterium linens
1.3
-
L-phenylalanine
pH 8.5, 37°C
Brevibacterium linens
1.4
-
L-tyrosine
pH 8.5, 37°C
Brevibacterium linens
8.4
-
L-aspartate
pH 8.5, 37°C
Brevibacterium linens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
126000
-
gel filtration
Brevibacterium linens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-phenylalanine + 2-oxoglutarate
Brevibacterium linens
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
-
-
L-phenylalanine + 2-oxoglutarate
Brevibacterium linens 47
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
Streptomycin sulfate and ammonium sulfate, DEAE-Trisacryl, HA-ultrogel, Sephacryl S-200, partial purification
Brevibacterium linens
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.8
-
with tyrosine
Brevibacterium linens
2.96
-
with aspartate
Brevibacterium linens
3.8
-
with tryptophan
Brevibacterium linens
6.5
-
with phenylalanine
Brevibacterium linens
Storage Stability (protein specific)
Storage Stability
Organism
4°C, 100 mM potassium phosphate buffer, pH 7.5, 0.002% NaN3, at least 6 months, no loss of activity
Brevibacterium linens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
aspartate + 2-oxoglutarate
-
636649
Brevibacterium linens
oxaloacetate + L-glutamate
-
636649
Brevibacterium linens
?
L-methionine + 2-oxoglutarate
-
636649
Brevibacterium linens
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
636649
Brevibacterium linens
?
L-phenylalanine + 2-oxoglutarate
completely inactive with D-isomers of aromatic amino acids
636649
Brevibacterium linens
phenylpyruvate + L-glutamate
-
636649
Brevibacterium linens
?
L-phenylalanine + 2-oxoglutarate
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
636649
Brevibacterium linens
phenylpyruvate + L-glutamate
-
-
-
-
L-phenylalanine + 2-oxoglutarate
completely inactive with D-isomers of aromatic amino acids
636649
Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
636649
Brevibacterium linens 47
?
L-phenylalanine + 2-oxoglutarate
probably key enzyme for utilization of aromatic amino acids as sole nitrogen source in Brevibacterium linens 47
636649
Brevibacterium linens 47
phenylpyruvate + L-glutamate
-
-
-
-
L-phenylalanine + oxaloacetate
-
636649
Brevibacterium linens
phenylpyruvate + L-aspartate
-
636649
Brevibacterium linens
?
L-phenylalanine + oxaloacetate
-
636649
Brevibacterium linens 47
phenylpyruvate + L-aspartate
-
636649
Brevibacterium linens 47
?
L-tryptophan + 2-oxoglutarate
-
636649
Brevibacterium linens
3-indole-2-oxopropanoate + L-glutamate
-
636649
Brevibacterium linens
?
L-tryptophan + 2-oxoglutarate
-
636649
Brevibacterium linens 47
3-indole-2-oxopropanoate + L-glutamate
-
636649
Brevibacterium linens 47
?
L-tryptophan + oxaloacetate
-
636649
Brevibacterium linens
3-indole-2-oxopropanoate + L-aspartate
-
636649
Brevibacterium linens
?
L-tyrosine + 2-oxoglutarate
-
636649
Brevibacterium linens
p-hydroxyphenylpyruvate + L-glutamate
-
636649
Brevibacterium linens
-
L-tyrosine + 2-oxoglutarate
-
636649
Brevibacterium linens 47
p-hydroxyphenylpyruvate + L-glutamate
-
636649
Brevibacterium linens 47
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
40
at pH 8.5
Brevibacterium linens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
9
phenylalanine
Brevibacterium linens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6.5
10
approx. 45% of maximal activity at pH 6.5, approx. 50% of maximal activity at pH 10
Brevibacterium linens
Other publictions for EC 2.6.1.57
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737334
Rzad
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2
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12
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7
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738333
Pieck
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Genetics
201
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-
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-
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3
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Saccharomyces cerevisiae
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-
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4
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-
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-
1
1
-
-
-
737425
Szkop
TyrB-2 and phhC genes of Pseud ...
Pseudomonas putida
Amino Acids
45
351-358
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-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
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10
1
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2
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10
2
-
-
-
-
-
-
-
-
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-
-
-
-
-
738949
Kulkarni
Indole-3-acetic acid biosynthe ...
Pantoea dispersa, Pantoea dispersa GPK
Lett. Appl. Microbiol.
56
340-347
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-
-
-
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6
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8
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723053
Hirata
Functional characterization of ...
Rosa hybrid cultivar
J. Plant Physiol.
169
444-451
2012
-
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1
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1
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1
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2
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6
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4
1
1
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1
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1
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1
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1
1
-
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1
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1
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6
-
-
4
1
1
-
-
-
1
-
-
1
-
1
1
-
-
-
723490
Castro-Guerrero
-
The hisC1 gene, encoding aroma ...
Azospirillum brasilense, Azospirillum brasilense Sp7
Plant Soil
356
139-150
2012
-
-
-
-
-
-
-
-
-
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2
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1
1
1
1
-
-
710489
Chen
Crystallization and preliminar ...
Saccharomyces cerevisiae
Protein Pept. Lett.
16
450-453
2009
-
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1
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1
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3
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1
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1
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1
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689666
Sergeeva
-
Production of indole-3-acetic ...
Pantoea agglomerans
Plant Soil
297
1-13
2007
-
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1
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1
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672710
Cho
Engineering aromatic L-amino a ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
94
842-850
2006
-
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1
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4
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5
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1
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8
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4
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1
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8
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672719
Cho
-
Asymmetric synthesis of unnatu ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) T30
Biotechnol. Bioprocess Eng.
11
299-305
2006
-
1
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2
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4
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1
1
4
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1
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4
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1
1
4
-
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-
-
-
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-
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-
677173
Fadnavis
-
Asymmetric synthesis of nonpro ...
Enterobacter sp., Enterobacter sp. BK2K-1
Tetrahedron
17
2199-2202
2006
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
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-
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4
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1
1
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4
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661783
Pedraza
Aromatic amino acid aminotrans ...
Azospirillum brasilense, Gluconacetobacter diazotrophicus, Pseudomonas stutzeri, Pseudomonas stutzeri A15
FEMS Microbiol. Lett.
233
15-21
2004
-
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5
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9
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16
2
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5
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16
2
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-
636676
Cho
Asymmetric synthesis of L-homo ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
83
226-234
2003
-
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1
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-
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7
-
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6
-
-
2
-
-
-
-
1
-
-
-
1
3
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
636653
Fazel
Aromatic aminotransferases in ...
Brevibacterium flavum, Corynebacterium ammoniagenes, Corynebacterium glutamicum
J. Bacteriol.
140
580-587
1979
-
-
-
-
-
-
3
-
-
-
5
-
-
6
-
-
3
-
-
-
-
-
15
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
5
-
-
-
-
3
-
-
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636647
Powell
The purification and propertie ...
Escherichia coli
Eur. J. Biochem.
87
391-400
1978
-
-
-
-
-
1
-
12
-
-
2
-
-
2
-
-
1
1
-
-
-
-
6
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
12
-
-
2
-
-
-
-
1
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
636658
Mavrides
Aminotransferases for aromatic ...
Bacillus subtilis
Biochim. Biophys. Acta
524
60-67
1978
-
-
-
-
-
-
-
7
-
-
2
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
2
-
-
-
-
1
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
636659
Weigent
Purification and properties of ...
Bacillus subtilis
J. Biol. Chem.
251
6974-6980
1976
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-
-
-
-
2
-
4
-
-
1
-
-
2
-
-
1
1
-
-
2
1
2
-
-
-
2
-
1
-
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
4
-
-
1
-
-
-
-
1
-
-
2
1
2
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
636643
Mavrides
Multispecific aspartate and ar ...
Escherichia coli
J. Biol. Chem.
250
4128-4133
1975
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-
-
-
-
-
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5
-
-
1
-
-
2
-
-
1
-
-
-
-
-
3
1
1
-
1
-
2
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
1
-
-
-
-
1
-
-
-
-
3
1
1
-
1
-
2
2
-
-
-
-
-
-
-
-
636660
Xing
Characterization of amino acid ...
Methanococcus aeolicus
J. Bacteriol.
174
541-548
1974
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-
-
-
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3
11
-
-
2
3
-
4
-
-
1
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
11
-
-
2
3
-
-
-
1
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
636656
Nakamura
Aromatic amino acid transamina ...
Rattus norvegicus
Biochem. J.
135
815-818
1973
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-
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-
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-
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2
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1
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-
2
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1
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1
-
2
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-
1
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