BRENDA - Enzyme Database show
show all sequences of 2.6.1.57

Transamination of aromatic amino acids in Escherichia coli

Mavrides, C.; Methods Enzymol. 142, 253-267 (1987)

Data extracted from this reference:

General Stability
General Stability
Organism
stable to freezing and thawing in phosphate buffers supplemented with pyridoxal phosphate, 2-oxoglutarate, dithiothreitol and EDTA
Escherichia coli
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.33
-
L-phenylalanine
pH 7.3, 37°C
Escherichia coli
0.62
-
L-tyrosine
pH 7.3, 37°C
Escherichia coli
2.5
-
2-oxoglutarate
pH 7.3, 37°C
Escherichia coli
3.13
-
oxaloacetate
pH 7.3, 37°C
Escherichia coli
10
-
L-tryptophan
pH 7.3, 37°C
Escherichia coli
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
88000
-
gel filtration
Escherichia coli
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate, 55°C, 5 min, calcium phosphate gel, DEAE-cellulose, isoelectric focusing
Escherichia coli
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
70.2
-
-
Escherichia coli
Storage Stability
Storage Stability
Organism
-25°C, protein concentration: 0.03-0.2 mg/ml, potassium phosphate pH 7.0, 1 mM EDTA, 1 mM dithiothreitol, 2 mM 2-oxoglutarate and 0.2 mM pyridoxal 5'-phosphate, several months, no loss of activity
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-iodo-L-tyrosine + 2-oxoglutarate
-
636645
Escherichia coli
3-(3-iodophenyl)-2-oxopropanoate + L-glutamate
-
636645
Escherichia coli
?
3-iodo-L-tyrosine + oxaloacetate
-
636645
Escherichia coli
3-(3-iodophenyl)-2-oxopropanoate + L-aspartate
-
636645
Escherichia coli
?
aspartate + 2-oxoglutarate
weak activity
636645
Escherichia coli
oxaloacetate + L-glutamate
-
636645
Escherichia coli
r
L-leucine + 2-oxoglutarate
weak activity
636645
Escherichia coli
4-methyl-2-oxopentanoate + L-glutamate
-
636645
Escherichia coli
?
L-methionine + 2-oxoglutarate
weak activity
636645
Escherichia coli
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
636645
Escherichia coli
?
L-phenylalanine + 2-oxoglutarate
-
636645
Escherichia coli
phenylpyruvate + L-glutamate
-
636645
Escherichia coli
-
L-phenylalanine + oxaloacetate
-
636645
Escherichia coli
phenylpyruvate + L-aspartate
-
636645
Escherichia coli
?
L-tryptophan + 2-oxoglutarate
weak activity
636645
Escherichia coli
3-indole-2-oxopropanoate + L-glutamate
-
636645
Escherichia coli
r
L-tryptophan + oxaloacetate
-
636645
Escherichia coli
3-indole-2-oxopropanoate + L-aspartate
-
636645
Escherichia coli
?
L-tyrosine + 2-oxoglutarate
-
636645
Escherichia coli
p-hydroxyphenylpyruvate + L-glutamate
-
636645
Escherichia coli
r
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
55
-
5% loss of activity after 5 min in the presence of 0.2 mM pyridoxal 5'-phosphate and 2 mM 2-oxoglutarate, 60% loss of activity in the absence of cofactor and substrate after 5 min, more than 90% after 10 min
Escherichia coli
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
152
-
L-phenylalanine
pH 7.3, 37°C
Escherichia coli
250
-
L-tryptophan
pH 7.3, 37°C
Escherichia coli
278
-
2-oxoglutarate
pH 7.3, 37°C
Escherichia coli
333
-
L-tyrosine
pH 7.3, 37°C
Escherichia coli
500
-
oxaloacetate
pH 7.3, 37°C
Escherichia coli
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
tryptophan
Escherichia coli
8
-
with phenylalanine; with tyrosine
Escherichia coli
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
a pyridoxal phosphate protein
Escherichia coli
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
a pyridoxal phosphate protein
Escherichia coli
General Stability (protein specific)
General Stability
Organism
stable to freezing and thawing in phosphate buffers supplemented with pyridoxal phosphate, 2-oxoglutarate, dithiothreitol and EDTA
Escherichia coli
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.33
-
L-phenylalanine
pH 7.3, 37°C
Escherichia coli
0.62
-
L-tyrosine
pH 7.3, 37°C
Escherichia coli
2.5
-
2-oxoglutarate
pH 7.3, 37°C
Escherichia coli
3.13
-
oxaloacetate
pH 7.3, 37°C
Escherichia coli
10
-
L-tryptophan
pH 7.3, 37°C
Escherichia coli
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
88000
-
gel filtration
Escherichia coli
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate, 55°C, 5 min, calcium phosphate gel, DEAE-cellulose, isoelectric focusing
Escherichia coli
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
70.2
-
-
Escherichia coli
Storage Stability (protein specific)
Storage Stability
Organism
-25°C, protein concentration: 0.03-0.2 mg/ml, potassium phosphate pH 7.0, 1 mM EDTA, 1 mM dithiothreitol, 2 mM 2-oxoglutarate and 0.2 mM pyridoxal 5'-phosphate, several months, no loss of activity
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-iodo-L-tyrosine + 2-oxoglutarate
-
636645
Escherichia coli
3-(3-iodophenyl)-2-oxopropanoate + L-glutamate
-
636645
Escherichia coli
?
3-iodo-L-tyrosine + oxaloacetate
-
636645
Escherichia coli
3-(3-iodophenyl)-2-oxopropanoate + L-aspartate
-
636645
Escherichia coli
?
aspartate + 2-oxoglutarate
weak activity
636645
Escherichia coli
oxaloacetate + L-glutamate
-
636645
Escherichia coli
r
L-leucine + 2-oxoglutarate
weak activity
636645
Escherichia coli
4-methyl-2-oxopentanoate + L-glutamate
-
636645
Escherichia coli
?
L-methionine + 2-oxoglutarate
weak activity
636645
Escherichia coli
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
636645
Escherichia coli
?
L-phenylalanine + 2-oxoglutarate
-
636645
Escherichia coli
phenylpyruvate + L-glutamate
-
636645
Escherichia coli
-
L-phenylalanine + oxaloacetate
-
636645
Escherichia coli
phenylpyruvate + L-aspartate
-
636645
Escherichia coli
?
L-tryptophan + 2-oxoglutarate
weak activity
636645
Escherichia coli
3-indole-2-oxopropanoate + L-glutamate
-
636645
Escherichia coli
r
L-tryptophan + oxaloacetate
-
636645
Escherichia coli
3-indole-2-oxopropanoate + L-aspartate
-
636645
Escherichia coli
?
L-tyrosine + 2-oxoglutarate
-
636645
Escherichia coli
p-hydroxyphenylpyruvate + L-glutamate
-
636645
Escherichia coli
r
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
55
-
5% loss of activity after 5 min in the presence of 0.2 mM pyridoxal 5'-phosphate and 2 mM 2-oxoglutarate, 60% loss of activity in the absence of cofactor and substrate after 5 min, more than 90% after 10 min
Escherichia coli
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
152
-
L-phenylalanine
pH 7.3, 37°C
Escherichia coli
250
-
L-tryptophan
pH 7.3, 37°C
Escherichia coli
278
-
2-oxoglutarate
pH 7.3, 37°C
Escherichia coli
333
-
L-tyrosine
pH 7.3, 37°C
Escherichia coli
500
-
oxaloacetate
pH 7.3, 37°C
Escherichia coli
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
tryptophan
Escherichia coli
8
-
with phenylalanine; with tyrosine
Escherichia coli
Other publictions for EC 2.6.1.57
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737334
Rzad
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Candida albicans, Candida albicans ATCC MYA-2876
Acta Biochim. Pol.
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903-912
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-
-
1
-
-
-
-
12
-
-
6
-
-
4
-
-
-
-
-
-
-
-
22
2
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
12
-
-
7
-
-
-
-
-
-
-
-
-
22
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
738333
Pieck
Auxin and tryptophan homeostas ...
Arabidopsis thaliana
Genetics
201
185-199
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
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-
-
-
-
-
-
1
1
-
-
-
739763
Romagnoli
Deletion of the Saccharomyces ...
Saccharomyces cerevisiae
Yeast
32
29-45
2015
-
1
-
-
-
-
-
-
-
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4
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1
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-
-
-
-
-
-
-
-
1
1
-
-
-
737425
Szkop
TyrB-2 and phhC genes of Pseud ...
Pseudomonas putida
Amino Acids
45
351-358
2013
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
10
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738949
Kulkarni
Indole-3-acetic acid biosynthe ...
Pantoea dispersa, Pantoea dispersa GPK
Lett. Appl. Microbiol.
56
340-347
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
8
-
-
-
-
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-
-
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-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723053
Hirata
Functional characterization of ...
Rosa hybrid cultivar
J. Plant Physiol.
169
444-451
2012
-
-
1
-
-
-
1
-
-
-
1
-
-
2
-
-
-
-
-
6
-
-
4
1
1
-
-
-
1
-
-
1
-
1
-
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
6
-
-
4
1
1
-
-
-
1
-
-
1
-
1
1
-
-
-
723490
Castro-Guerrero
-
The hisC1 gene, encoding aroma ...
Azospirillum brasilense, Azospirillum brasilense Sp7
Plant Soil
356
139-150
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
710489
Chen
Crystallization and preliminar ...
Saccharomyces cerevisiae
Protein Pept. Lett.
16
450-453
2009
-
-
-
1
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
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-
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-
-
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1
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1
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-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689666
Sergeeva
-
Production of indole-3-acetic ...
Pantoea agglomerans
Plant Soil
297
1-13
2007
-
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672710
Cho
Engineering aromatic L-amino a ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
94
842-850
2006
-
-
1
-
4
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
8
-
-
-
-
-
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-
-
-
-
-
-
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-
1
-
-
4
-
-
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1
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-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672719
Cho
-
Asymmetric synthesis of unnatu ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) T30
Biotechnol. Bioprocess Eng.
11
299-305
2006
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
1
1
4
-
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
4
-
1
1
4
-
-
-
-
-
-
-
-
-
-
-
677173
Fadnavis
-
Asymmetric synthesis of nonpro ...
Enterobacter sp., Enterobacter sp. BK2K-1
Tetrahedron
17
2199-2202
2006
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
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-
-
-
-
-
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-
-
1
1
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661783
Pedraza
Aromatic amino acid aminotrans ...
Azospirillum brasilense, Gluconacetobacter diazotrophicus, Pseudomonas stutzeri, Pseudomonas stutzeri A15
FEMS Microbiol. Lett.
233
15-21
2004
-
-
-
-
-
-
-
-
-
-
5
-
-
9
-
-
-
-
-
-
-
-
16
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
16
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636676
Cho
Asymmetric synthesis of L-homo ...
Enterobacter sp., Enterobacter sp. BK2K-1
Biotechnol. Bioeng.
83
226-234
2003
-
-
1
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660743
Chambellon
CodY-regulated aminotransferas ...
Lactococcus lactis
Appl. Environ. Microbiol.
69
3061-3068
2003
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
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-
-
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-
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1
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1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661888
Rijnen
-
Lactococcal aminotransferases ...
Lactococcus lactis
Int. Dairy J.
13
805-812
2003
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
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Mavrides
Aminotransferases for aromatic ...
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1978
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2
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Weigent
Purification and properties of ...
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1
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4
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1
2
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2
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Mavrides
Multispecific aspartate and ar ...
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5
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3
1
1
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636660
Xing
Characterization of amino acid ...
Methanococcus aeolicus
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1974
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6
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3
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11
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3
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6
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1
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636656
Nakamura
Aromatic amino acid transamina ...
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1973
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