Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.52 extracted from

  • Wulfert, S.; Krueger, S.
    Phosphoserine aminotransferase1 is part of the phosphorylated pathways for serine biosynthesis and essential for light and sugar-dependent growth promotion (2018), Front. Plant Sci., 871, 1712 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.52

Cloned(Commentary)

Cloned (Comment) Organism
gene PSAT1 Arabidopsis thaliana
gene PSAT2 Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information PSAT1-silenced lines (ts-psat1.1 and ts-psat1.2) are generated for functional characterization using a microRNA-based approach. Overexpression of the artificial PSAT1-silencing construct in Arabidopsis thaliana leads to a significant reduction of PSAT1 expression, which subsequently results in a strong inhibition of growth. The expression of the PSAT2 gene is unaltered in PSAT1-silenced plants, phenotype, overview Arabidopsis thaliana
additional information PSAT1-silenced lines (ts-psat1.1 and ts-psat1.2) are generated for functional characterization using a microRNA-based approach. The expression of the PSAT2 gene is unaltered in PSAT1-silenced plants, phenotype, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-phospho-L-serine + 2-oxoglutarate Arabidopsis thaliana
-
 3-phosphooxypyruvate + L-glutamate
-
 r

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q96255
-
-
Arabidopsis thaliana Q9SHP0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cotyledon
-
 Arabidopsis thaliana
-
leaf
-
 Arabidopsis thaliana
-
additional information PSAT1 is the most expressed isoform and the expression of both genes is higher in root than in shoot tissue. In 10-days-old plants the activity of both PSAT gene promoters is high in the shoot apical meristem (SAM), the root apical meristem (RAM), in the vasculature of the hypocotyl and in the vasculature of roots, whereas the PSAT1 promoter is additionally active in the vasculature tissue of cotyledons and young leaves. Specific expression pattern of PSAT genes, overview Arabidopsis thaliana
-
root
-
 Arabidopsis thaliana
-
shoot
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-phospho-L-serine + 2-oxoglutarate
-
 Arabidopsis thaliana 3-phosphooxypyruvate + L-glutamate
-
 r

Synonyms

Synonyms Comment Organism
phosphoserine aminotransferase1
-
 Arabidopsis thaliana
phosphoserine aminotransferase2
-
 Arabidopsis thaliana
PSAT1
-
 Arabidopsis thaliana
PSAT2
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate PLP Arabidopsis thaliana

General Information

General Information Comment Organism
evolution the Arabidopsis genome contains three genes for the PGDH (At4g34200/PGDH1, At1g17745/ PGDH2, and At3g19480/ PGDH3), two genes for the PSAT (At4g35630/PSAT1, and At2g17630/PSAT2) and one gene for the PSP (At1g18640). The PSAT1 gene is the most expressed isoform in Arabidopsis thaliana Arabidopsis thaliana
malfunction a growth phenotype is observed for PSAT1-silenced plants due to serine deficiency Arabidopsis thaliana
metabolism the serine biosynthesis pathway consists of three sequential reactions that are catalyzed by 3-phosphoglycerate dehydrogenase (PGDH), 3-phosphoserine aminotransferase (PSAT), and 3-phosphoserine phosphatase (PSP) enzymes, all localized in the plastids. Serine biosynthesis pathways in plants, overview Arabidopsis thaliana
physiological function phosphoserine aminotransferase1 is part of the phosphorylated pathways for serine biosynthesis and essential for light and sugar-dependent growth promotion Arabidopsis thaliana