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Literature summary for 2.6.1.52 extracted from
- Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis (2003), Biochem. J., 373, 191-200.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | useful for creating a new concept or target for the diagnosis and therapy of human serine metabolism-related disorders and cancer | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| 2 forms results from alternative splicing, PSATalpha and PSATbeta, cDNA cloned and expressed in Escherichia coli and in human cell lines, leukaemia Jurkat, colon adenocarcinoma COLO 320DM, heptacellular carcinoma HepG2 and weakly in leukaemia MOLT-3, complementation of Saccharomyces cerevisiae SER-1 deletion mutation | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35200 | - |
PSATalpha, predicted from cDNA | Homo sapiens |
| 40000 | - |
PSATbeta, predicted from cDNA | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate + 3-phosphohydroxypyruvate | Homo sapiens | phosphorylated pathway for serine biosynthesis | O-phospho-L-serine + 2-oxoglutarate | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y617 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | mRNA expressed in | Homo sapiens | - |
| kidney | mRNA expressed in | Homo sapiens | - |
| liver | mRNA expressed in | Homo sapiens | - |
| additional information | very weak mRNA expression in thymus,prostate, testis and colon | Homo sapiens | - |
| pancreas | mRNA expressed in | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate + 3-phosphohydroxypyruvate | - |
Homo sapiens | O-phospho-L-serine + 2-oxoglutarate | - |
r | |
| L-glutamate + 3-phosphohydroxypyruvate | phosphorylated pathway for serine biosynthesis | Homo sapiens | O-phospho-L-serine + 2-oxoglutarate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PSAT alpha | - |
Homo sapiens |
| PSAT beta | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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