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Literature summary for 2.6.1.49 extracted from

  • Waterhouse, M.J.; Chia, Y.C.; Lees, G.J.
    Inhibition of human and rat hepatic aminotransferase activity with L-3,4-dihydroxyphenylalanine by inhibitors of peripheral aromatic amino acid decarboxylase (1979), Mol. Pharmacol., 15, 108-114.
    View publication on PubMed
Search for more literature for 2.6.1.49

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxy-4-benzyloxyamine dihydrogen phosphate NSD 1055, up to 30 mM Homo sapiens
3-hydroxy-4-benzyloxyamine dihydrogen phosphate NSD 1055, up to 30 mM Rattus norvegicus
carbidopa MK 486, inhibition is more marked if 2-oxoglutarate is used as amino group acceptor rather than phenylpyruvate, pyridoxal 5'-phosphate protects Rattus norvegicus
additional information not inhibited by benserazide Homo sapiens
additional information not inhibited by benserazide Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate i.e. L-dopa Homo sapiens 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate i.e. DOPP ?
3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate i.e. L-dopa Rattus norvegicus 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate i.e. DOPP ?
3-(3,4-dihydroxyphenyl)-L-alanine + 3-phenylpyruvate i.e. L-dopa Homo sapiens 3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine
-
 ?
3-(3,4-dihydroxyphenyl)-L-alanine + 3-phenylpyruvate i.e. L-dopa Rattus norvegicus 3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine
-
 ?
L-tyrosine + 2-oxoglutarate 8% of activity with L-Dopa Homo sapiens 3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?
L-tyrosine + 2-oxoglutarate 8% of activity with L-Dopa Rattus norvegicus 3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?