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Literature summary for 2.6.1.44 extracted from

  • Rumsby, G.; Weir, T.; Samuell, C.T.
    A semiautomated alanine:glyoxylate aminotransferase assay for the tissue diagnosis of primary hyperoxaluria type 1 (1997), Ann. Clin. Biochem., 34, 400-404.
No PubMed abstract available
Search for more literature for 2.6.1.44

Application

Application Comment Organism
medicine hereditary disease primary hyperoxaluria type 1 is caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase, diagnosis with selective inhibitors and enzyme assays Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
 glyoxylate pH 8.0, 37°C, L-alanine as amino donor Homo sapiens
13.5
-
 L-alanine pH 8.0, 37°C, glyoxylate as amino acceptor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + glyoxylate Homo sapiens
-
 pyruvate + glycine
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + glyoxylate
-
 Homo sapiens pyruvate + glycine
-
 ir

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 8
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 8.2
-
 Homo sapiens