BRENDA - Enzyme Database
show all sequences of 2.6.1.40

Irreversible inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by gabaculine

Kaneko, M.; Fujimoto, S.; Kikugawa, M.; Tamaki, N.; FEBS Lett. 276, 115-118 (1990)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
gabaculine
i.e. 5-amino-1,3-cyclohexadienylcarboxylate, strong, irreversible, beta-alanine or pyruvate protects, 4-aminobutyrate to a lesser extent, not 2-oxoglutarate
Rattus norvegicus
Organism
Organism
UniProt
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
gabaculine
i.e. 5-amino-1,3-cyclohexadienylcarboxylate, strong, irreversible, beta-alanine or pyruvate protects, 4-aminobutyrate to a lesser extent, not 2-oxoglutarate
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
Other publictions for EC 2.6.1.40
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737947
Abe
Distribution of D-3-aminoisobu ...
Rattus norvegicus
BMC Neurosci.
15
53
2014
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636964
Tamaki
Purification, properties, and ...
Rattus norvegicus
Methods Enzymol.
324
376-389
2000
-
-
-
-
-
-
2
-
-
-
2
-
-
1
-
-
1
-
-
1
2
1
7
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
2
-
-
-
-
1
-
1
2
1
7
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
644431
Kontani
Identity of D-3-aminoisobutyra ...
Rattus norvegicus
Biochim. Biophys. Acta
1156
161-166
1993
-
-
-
-
-
-
11
-
-
-
1
-
-
2
-
-
-
1
-
2
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
11
-
-
-
-
1
-
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
637062
Kaneko
Inhibition of D-3-aminoisobuty ...
Rattus norvegicus
Biochim. Biophys. Acta
1122
45-49
1992
-
-
-
-
-
-
12
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
637049
Kaneko
Irreversible inhibition of D-3 ...
Rattus norvegicus
FEBS Lett.
276
115-118
1990
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
644426
Tamaki
Purification, characterization ...
Rattus norvegicus
Eur. J. Biochem.
189
39-45
1990
-
-
-
-
-
-
6
2
1
-
2
-
-
2
-
-
1
-
-
3
-
1
9
1
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
6
-
2
1
-
2
-
-
-
-
1
-
3
-
1
9
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
644430
Ueno
Purification and characterizat ...
Rattus norvegicus
Biochim. Biophys. Acta
1033
169-175
1990
2
-
-
-
-
-
2
-
1
-
2
-
-
2
-
-
1
-
-
2
1
2
12
1
-
1
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
2
-
-
1
-
2
-
-
-
-
1
-
2
1
2
12
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
644428
Kakimoto
D-beta-Aminoisobutyrate:pyruva ...
Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
244
335-340
1969
2
-
-
-
-
-
1
1
-
-
-
4
-
4
-
-
1
-
-
7
1
1
19
-
-
4
-
-
-
1
1
-
2
-
-
-
2
-
-
2
-
-
-
-
1
-
1
-
-
-
4
-
-
-
1
-
7
1
1
19
-
4
-
-
-
1
1
-
-
-
-
-
-
-
-