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Literature summary for 2.6.1.40 extracted from
- Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver (2000), Methods Enzymol., 324, 376-389.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-fluoro-beta-alanine | - |
Rattus norvegicus |  |
| gabaculine | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
4 * 52000, SDS-PAGE | Rattus norvegicus |
| 220000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay principle | Rattus norvegicus |
| 11.3 | - |
pH 8.8, 37°C | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 0.05 mg protein/ml, in 0.1 M potassium phosphate buffer, pH 7, 1 mM EDTA, 2 mM 2-mercaptoethanol, about 50% loss of activity within a few days, 80% loss within 1 week | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-3-amino-2-methylpropanoate + glyoxylate | with 90% efficiency compared to pyruvate | Rattus norvegicus | 2-methyl-3-oxopropanoate + glycine | - |
r | |
| (R)-3-amino-2-methylpropanoate + oxaloacetate | with 63% efficiency compared to pyruvate | Rattus norvegicus | 2-methyl-3-oxopropanoate + L-aspartate | - |
r | |
| beta-alanine + pyruvate | transamination at 66% the rate of (R)-3-amino-2-methylpropanoate | Rattus norvegicus | malonic semialdehyde + L-alanine | - |
? | |
| additional information | overview | Rattus norvegicus | ? | - |
? | |
| additional information | no substrate: 2-oxoglutarate | Rattus norvegicus | ? | - |
? | |
| additional information | gamma-aminobutanoate is neither substrate nor inhibitor | Rattus norvegicus | ? | - |
? | |
| additional information | no substrate: phenylpyruvate | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 52000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | - |
- |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | gamma-aminobutanoate is neither substrate nor inhibitor | Rattus norvegicus |
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Release 2023.1 (January 2023)
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