BRENDA - Enzyme Database
show all sequences of 2.6.1.40

Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine-glyoxylate aminotransferase 2

Kontani, M.; Kaneko, M.; Kikugawa, M.; Fujimoto, S.; Tamaki, N.; Biochim. Biophys. Acta 1156, 161-166 (1993)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(R)-3-Amino-2-methylpropanoate
beta-alanine as substrate
Rattus norvegicus
(S)-2-aminobutyrate
beta-alanine as substrate
Rattus norvegicus
(S)-alanine
with beta-alanine + glyoxylate as substrate, not (R)-isomer
Rattus norvegicus
5-aminolevulinic acid
beta-alanine as substrate
Rattus norvegicus
5-fluorouracil
-
Rattus norvegicus
6-Azathymine
weak
Rattus norvegicus
6-Azauracil
-
Rattus norvegicus
beta-Alanine
with (S)-alanine + glyoxylate as substrate
Rattus norvegicus
glyoxylate
at high concentrations
Rattus norvegicus
NG,NG'-dimethyl-(S)-arginine
beta-alanine as substrate
Rattus norvegicus
pyruvate
at high concentrations
Rattus norvegicus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
180000
-
gel filtration
Rattus norvegicus
Organism
Organism
UniProt
Commentary
Textmining
Rattus norvegicus
-
-
-
Reaction
Reaction
Commentary
Organism
Reaction ID
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
may be identical with alanine-glyoxylate aminotransferase, EC 2.6.1.44
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
(R)-3-amino-2-methylpropanoate + glyoxylate
-
644431
Rattus norvegicus
2-methyl-3-oxopropanoate + glycine
-
-
-
?
(S)-2-aminobutyrate + pyruvate
-
644431
Rattus norvegicus
2-oxobutanoate + L-alanine
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(R)-3-Amino-2-methylpropanoate
beta-alanine as substrate
Rattus norvegicus
(S)-2-aminobutyrate
beta-alanine as substrate
Rattus norvegicus
(S)-alanine
with beta-alanine + glyoxylate as substrate, not (R)-isomer
Rattus norvegicus
5-aminolevulinic acid
beta-alanine as substrate
Rattus norvegicus
5-fluorouracil
-
Rattus norvegicus
6-Azathymine
weak
Rattus norvegicus
6-Azauracil
-
Rattus norvegicus
beta-Alanine
with (S)-alanine + glyoxylate as substrate
Rattus norvegicus
glyoxylate
at high concentrations
Rattus norvegicus
NG,NG'-dimethyl-(S)-arginine
beta-alanine as substrate
Rattus norvegicus
pyruvate
at high concentrations
Rattus norvegicus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
180000
-
gel filtration
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
(R)-3-amino-2-methylpropanoate + glyoxylate
-
644431
Rattus norvegicus
2-methyl-3-oxopropanoate + glycine
-
-
-
?
(S)-2-aminobutyrate + pyruvate
-
644431
Rattus norvegicus
2-oxobutanoate + L-alanine
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
Other publictions for EC 2.6.1.40
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737947
Abe
Distribution of D-3-aminoisobu ...
Rattus norvegicus
BMC Neurosci.
15
53
2014
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
636964
Tamaki
Purification, properties, and ...
Rattus norvegicus
Methods Enzymol.
324
376-389
2000
-
-
-
-
-
-
2
-
-
-
2
-
-
1
-
-
1
-
-
1
2
1
7
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
2
-
-
-
-
1
-
1
2
1
7
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
644431
Kontani
Identity of D-3-aminoisobutyra ...
Rattus norvegicus
Biochim. Biophys. Acta
1156
161-166
1993
-
-
-
-
-
-
11
-
-
-
1
-
-
2
-
-
-
1
-
2
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
11
-
-
-
-
1
-
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
637062
Kaneko
Inhibition of D-3-aminoisobuty ...
Rattus norvegicus
Biochim. Biophys. Acta
1122
45-49
1992
-
-
-
-
-
-
12
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
637049
Kaneko
Irreversible inhibition of D-3 ...
Rattus norvegicus
FEBS Lett.
276
115-118
1990
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
644426
Tamaki
Purification, characterization ...
Rattus norvegicus
Eur. J. Biochem.
189
39-45
1990
-
-
-
-
-
-
6
2
1
-
2
-
-
2
-
-
1
-
-
3
-
1
9
1
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
6
-
2
1
-
2
-
-
-
-
1
-
3
-
1
9
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
644430
Ueno
Purification and characterizat ...
Rattus norvegicus
Biochim. Biophys. Acta
1033
169-175
1990
2
-
-
-
-
-
2
-
1
-
2
-
-
2
-
-
1
-
-
2
1
2
12
1
-
1
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
2
-
-
1
-
2
-
-
-
-
1
-
2
1
2
12
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
644428
Kakimoto
D-beta-Aminoisobutyrate:pyruva ...
Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
244
335-340
1969
2
-
-
-
-
-
1
1
-
-
-
4
-
4
-
-
1
-
-
7
1
1
19
-
-
4
-
-
-
1
1
-
2
-
-
-
2
-
-
2
-
-
-
-
1
-
1
-
-
-
4
-
-
-
1
-
7
1
1
19
-
4
-
-
-
1
1
-
-
-
-
-
-
-
-