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Literature summary for 2.6.1.36 extracted from

  • Parthiban, B.; Saxena, S.; Chandran, M.; Jonnalagadda, P.; Yadav, R.; Srilakshmi, R.; Perumal, Y.; Dharmarajan, S.
    Design and development of Mycobacterium tuberculosis lysine epsilon-aminotransferase inhibitors for latent tuberculosis infection (2016), Chem. Biol. Drug Des., 87, 265-274.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2,2'-oxybis[N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide] 25.6% cytotoxicity at 0.1 mM Mycobacterium tuberculosis
2,2'-oxybis[N'-[(E)-[(3-benzyloxy)phenyl]methylidene]acetohydrazide] 26.4% cytotoxicity at 0.1 mM Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQ77
-
-
Mycobacterium tuberculosis H37Rv P9WQ77
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00081
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 2,2'-oxybis[N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide]
0.0019
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 2,2'-oxybis[N'-[(E)-[(3-benzyloxy)phenyl]methylidene]acetohydrazide]