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Literature summary for 2.6.1.2 extracted from
- Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin An in vitro and in silico study (2017), Life Sci., 178, 49-55 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hesperidin | - |
Rattus norvegicus |  |
| hesperitin | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + 2-oxoglutarate | Rattus norvegicus | - |
pyruvate + L-glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + 2-oxoglutarate | - |
Rattus norvegicus | pyruvate + L-glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alanine aminotransferase | - |
Rattus norvegicus |
| ALT | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0688 | - |
at pH 7.4 and 37°C | Rattus norvegicus | hesperidin | |
| 0.1539 | - |
at pH 7.4 and 37°C | Rattus norvegicus | hesperitin | |
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