Application | Comment | Organism |
---|---|---|
medicine | attenuating GABAT activity and enhancing GABA expression are a promising way to relieve spasticity following stroke. The modulation of GABA and its metabolism by acupuncture, particularly waggle needling, might attenuate GABAT and enhance GABA, alleviating post-stroke spasticity. Waggle needling decreases cerebral infarction and alleviates neurological deficits, overview. No significant difference is found between waggle needling group and baclofen group | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanoate + 2-oxoglutarate | Rattus norvegicus | - |
succinate semialdehyde + L-glutamate | - |
? | |
4-aminobutanoate + 2-oxoglutarate | Rattus norvegicus Sprague-Dawley | - |
succinate semialdehyde + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P50554 | - |
- |
Rattus norvegicus Sprague-Dawley | P50554 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanoate + 2-oxoglutarate | - |
Rattus norvegicus | succinate semialdehyde + L-glutamate | - |
? | |
4-aminobutanoate + 2-oxoglutarate | - |
Rattus norvegicus Sprague-Dawley | succinate semialdehyde + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ABAT | - |
Rattus norvegicus |
GABA transaminase | - |
Rattus norvegicus |
GABAT | - |
Rattus norvegicus |
gamma-aminobutyric acid transaminase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | waggle needling attenuates gamma-aminobutyric acid transaminase expression in the injured brain of rats with post-stroke spasticity | down |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of GABAT is known to boost GABA concentration in the brain and thereby alleviates spasticity. Therefore, attenuating GABAT activity and enhancing GABA expression are a promising way to relieve spasticity following stroke. Waggle needling attenuates gamma-aminobutyric acid transaminase expression in the injured brain of rats with post-stroke spasticity comparable to the effect of baclofen | Rattus norvegicus |
metabolism | GABA transaminase (GABAT) is the key catabolic enzyme of GABA metabolism | Rattus norvegicus |
physiological function | gamma-aminobutyric acid (GABA) is one of the chief inhibitory neurotransmitters in the central nerve system (CNS), plays pre- or postsynaptic inhibitory effects. GABA transaminase (GABAT) is the key catabolic enzyme of GABA metabolism. The modulation of GABA and its metabolism by acupuncture, particularly waggle needling, might attenuate GABAT and enhance GABA, alleviating post-stroke spasticity | Rattus norvegicus |