Literature summary for 2.6.1.19 extracted from

Patel, A.B.; de Graaf, R.A.; Martin, D.L.; Battaglioli, G.; Behar, K.L.
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo (2006), J. Neurochem., 97, 385-396.

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Inhibitors

Inhibitors	Comment	Organism	Structure
gabaculine	IC50: 0.0018 mM, potent and irreversible inhibitor	Rattus norvegicus
vigabatrin	IC50: 0.35 mM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-aminobutanoate + 2-oxoglutarate	-	Rattus norvegicus	4-oxobutanoate + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
GABA-T	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0018	-	IC50: 0.0018 mM, potent and irreversible inhibitor	Rattus norvegicus	gabaculine
0.35	-	IC50: 0.35 mM	Rattus norvegicus	vigabatrin

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Release 2023.1 (January 2023)