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Literature summary for 2.6.1.19 extracted from
- Purification and partial characterization of 4-aminobutyrate:2-oxoglutarate aminotransferase from sheep brain and locust ganglia (1988), Biochem. J., 249, 795-799.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,4-diaminobutanoate | not | Ovis aries |  |
| 2,4-diaminobutanoate | not | Schistocerca gregaria | |
| gabaculine | - |
Ovis aries | |
| gabaculine | - |
Schistocerca gregaria | |
| additional information | - |
Ovis aries | |
| additional information | no inhibition by 3-aminopropane-1-sulfonic acid, isoguvacine (i.e. 1,2,3,4-tetrahydro-1-methyl-3-pyridine carboxylic acid), baclofen (i.e. beta-(aminomethyl)-4-chlorobenzenepropanoic acid), bicuculline, picrotoxin, Schistocerca gregaria: antiserum against sheep enzyme | Schistocerca gregaria | |
| Muscimol | i.e. 5-(aminomethyl)-3-isoxazolol | Ovis aries | |
| Muscimol | i.e. 5-(aminomethyl)-3-isoxazolol | Schistocerca gregaria | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.22 | - |
2-oxoglutarate | pH 8.5 | Ovis aries | |
| 0.27 | - |
2-oxoglutarate | pH 8.5 | Schistocerca gregaria | |
| 0.79 | - |
4-aminobutanoate | pH 8.5 | Schistocerca gregaria | |
| 2.2 | 2.3 | 4-aminobutanoate | - |
Ovis aries | |
| 2.2 | 2.3 | 4-aminobutanoate | pH 8.5 | Schistocerca gregaria | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Schistocerca gregaria | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
2 * 50000, SDS-PAGE | Ovis aries |
| 97000 | - |
gel filtration | Ovis aries |
| 97000 | - |
gel filtration | Schistocerca gregaria |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
| Schistocerca gregaria | - |
locust | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Ovis aries |
- |
Schistocerca gregaria |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Ovis aries | - |
| ganglion | supraoesophageal | Schistocerca gregaria | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.1 | - |
- |
Ovis aries |
| 4.36 | - |
- |
Schistocerca gregaria |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-aminobutanoate + 2-oxoglutarate | - |
Ovis aries | 4-oxobutanoate + L-glutamate | - |
r | |
| 4-aminobutanoate + 2-oxoglutarate | - |
Schistocerca gregaria | 4-oxobutanoate + L-glutamate | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 50000, SDS-PAGE | Ovis aries |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 13.2 | - |
4-aminobutanoate | - |
Ovis aries | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 5.5 | Ovis aries |
| additional information | - |
pI: 6.7 | Schistocerca gregaria |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Ovis aries | |
| pyridoxal 5'-phosphate | - |
Schistocerca gregaria | |
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