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Literature summary for 2.6.1.16 extracted from

  • Sanchez-Lopez, J.F.; Gonzalez-Ibarra, J.; Macias-Segoviano, J.I.; Cuellar-Cruz, M.; Alvarez-Vargas, A.; Cano-Canchola, C.; Lopez-Romero, E.
    Congo Red affects the growth, morphology and activity of glucosamine-6-phosphate synthase in the human pathogenic fungus Sporothrix schenckii (2019), Arch. Microbiol., 201, 135-141 .
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
Congo red CR, affects the growth, morphology, and activity of glucosamine-6-phosphate synthase in human pathogenic fungus Sporothrix schenckii. Under conditions of yeast development, 0.015 mM CR abolishes conidia germination, but when yeast cells are first obtained in the absence of the dye and then post-incubated in its presence, yeasts rapidly differentiate into mycelial cells. On the other hand, under conditions of mycelium development, 0.150 mM CR do not affect conidia germination, but filamentous cells undergo structural changes characterized by a distorted cell wall contour, the loss of polarity and the formation of red-pigmented, hyphal globose structures. Under these conditions, CR also induces a significant and transient increase in the activity of GlcN-6-P synthase, an essential enzyme in cell wall biogenesis Sporothrix schenckii

Inhibitors

Inhibitors Comment Organism Structure
Congo red CR, affects the growth, morphology, and activity of glucosamine-6-phosphate synthase in human pathogenic fungus Sporothrix schenckii. Under conditions of yeast development, 0.015 mM CR abolishes conidia germination, but when yeast cells are first obtained in the absence of the dye and then post-incubated in its presence, yeasts rapidly differentiate into mycelial cells. On the other hand, under conditions of mycelium development, 0.150 mM CR do not affect conidia germination, but filamentous cells undergo structural changes characterized by a distorted cell wall contour, the loss of polarity and the formation of red-pigmented, hyphal globose structures. Under these conditions, CR also induces a significant and transient increase in the activity of GlcN-6-P synthase, an essential enzyme in cell wall biogenesis Sporothrix schenckii

Organism

Organism UniProt Comment Textmining
Sporothrix schenckii D2KR34
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-

Source Tissue

Source Tissue Comment Organism Textmining
additional information conditions to obtain the yeast (pH 7.0, 37°C) or the mycelial (pH 4.5, 28°C) morphotypes. Congo Red (CR) affects the growth, morphology, and activity of glucosamine-6-phosphate synthase in human pathogenic fungus Sporothrix schenckii. Under conditions of yeast development, 0.015 mM CR abolishes conidia germination, but when yeast cells are first obtained in the absence of the dye and then post-incubated in its presence, yeasts rapidly differentiate into mycelial cells. On the other hand, under conditions of mycelium development, 0.150 mM CR do not affect conidia germination, but filamentous cells undergo structural changes characterized by a distorted cell wall contour, the loss of polarity and the formation of red-pigmented, hyphal globose structures. Under these conditions, CR also induces a significant and transient increase in the activity of GlcN-6-P synthase, an essential enzyme in cell wall biogenesis Sporothrix schenckii
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mycelium
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 Sporothrix schenckii
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yeast form
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 Sporothrix schenckii
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Synonyms

Synonyms Comment Organism
GlcN-6-P synthase
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 Sporothrix schenckii
glucosamine-6-phosphate synthase
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 Sporothrix schenckii