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Literature summary for 2.6.1.14 extracted from

  • Moriya, Y.; Yamada, T.; Okuda, S.; Nakagawa, Z.; Kotera, M.; Tokimatsu, T.; Kanehisa, M.; Goto, S.
    Identification of enzyme genes using chemical structure alignments of substrate-product pairs (2016), J. Chem. Inf. Model., 56, 510-516 .
    View publication on PubMed
Search for more literature for 2.6.1.14

Cloned(Commentary)

Cloned (Comment) Organism
the gene SMU_1312 encoding the enzyme is not directly identified, but the paralogue gene most similar to the asparagine oxo-acid transaminase gene SMU_24 is identified Streptococcus mutans serotype c

Organism

Organism UniProt Comment Textmining
Streptococcus mutans serotype c Q8DTM1
-
-
Streptococcus mutans serotype c ATCC 700610 Q8DTM1
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-
Streptococcus mutans serotype c UA159 Q8DTM1
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-asparagine + L-glutamate
-
 Streptococcus mutans serotype c 2-oxosuccinamate + L-glutamine
-
 ?
L-asparagine + L-glutamate
-
 Streptococcus mutans serotype c ATCC 700610 2-oxosuccinamate + L-glutamine
-
 ?
L-asparagine + L-glutamate
-
 Streptococcus mutans serotype c UA159 2-oxosuccinamate + L-glutamine
-
 ?

Synonyms

Synonyms Comment Organism
asparagine oxo-acid transaminase
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 Streptococcus mutans serotype c
aspB
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 Streptococcus mutans serotype c
SMU_1312
-
 Streptococcus mutans serotype c

General Information

General Information Comment Organism
additional information development and evaluation of a method for the prediction of possible genes of orphan enzyme reactions where any associated gene sequences are not determined to date. The candidate enzyme gene of a reaction is detected using the chemical structures of the substrate-product pair (reactant pair). The proposed method is based on a search for similar reactant pairs in a reference database (KEGG database) and offers orthologeous groups that possibly mediate the given reaction. One example is the asparagine oxo-acid transaminase (R01346, EC 2.6.1.14), which transfers an amino group from asparagine to glutamate, the paralogue reactant pair is the asparagine-oxaloacetamide pair correlated to gene SMU_24 (UniProt ID Q8DWM1) Streptococcus mutans serotype c