Literature summary for 2.6.1.13 extracted from

Levillain, O.; Diaz, J.J.; Blanchard, O.; Dechaud, H.
Testosterone down-regulates ornithine aminotransferase gene and up-regulates arginase II and ornithine decarboxylase genes for polyamines synthesis in the murine kidney (2005), Endocrinology, 146, 950-959.

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Application

Application	Comment	Organism
medicine	pharmacological doses of testosterone down-regulate level of enzyme protein. Variations of levels of enzyme are strongly correlated with testosteronemia. Orchidectomy increases renal level of enzyme protein. Effects are reversed by injecting physiological doses of testosterone into castrated male animals	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P29758	female and castrated male animals	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)