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Literature summary for 2.6.1.120 extracted from
- An extended bacterial reductive pyrimidine degradation pathway that enables nitrogen release from beta-alanine (2019), J. Biol. Chem., 294, 15662-15671 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.3 | - |
beta-Alanine | pH 8, temperature not specified in the publication | Ureibacillus massiliensis |  |
| 3.3 | - |
2-oxoglutarate | pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 12 | - |
taurine | cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 46 | - |
pyruvate | cosubstrate beta-alanine, pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-alanine + 2-oxoglutarate | Ureibacillus massiliensis | - |
3-oxopropanoate + L-glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ureibacillus massiliensis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-alanine + 2-oxoglutarate | - |
Ureibacillus massiliensis | 3-oxopropanoate + L-glutamate | - |
? | |
| beta-alanine + 2-oxoglutarate | - |
Ureibacillus massiliensis | 3-oxopropanoate + L-glutamate | - |
r | |
| beta-alanine + oxaloacetate | - |
Ureibacillus massiliensis | 3-oxopropanoate + ? | - |
r | |
| beta-alanine + pyruvate | - |
Ureibacillus massiliensis | 3-oxopropanoate + L-alanine | - |
r | |
| taurine + 2-oxoglutarate | - |
Ureibacillus massiliensis | ? + L-glutamate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pydD | - |
Ureibacillus massiliensis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.51 | - |
taurine | cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 1.25 | - |
pyruvate | cosubstrate beta-alanine, pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 5.6 | - |
2-oxoglutarate | pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 5.6 | - |
beta-Alanine | pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Ureibacillus massiliensis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | beta-alanine:2-oxoglutarate aminotransferase PydD and NAD(P)H-dependent malonic semialdehyde reductase PydE together convert beta-alanine into 3-hydroxypropionate and generated glutamate, thereby making the second nitrogen from the pyrimidine ring available for assimilation | Ureibacillus massiliensis |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.027 | - |
pyruvate | cosubstrate beta-alanine, pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 0.041 | - |
taurine | cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 1.7 | - |
2-oxoglutarate | pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
| 2.4 | - |
beta-Alanine | pH 8, temperature not specified in the publication | Ureibacillus massiliensis | |
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