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Literature summary for 2.6.1.120 extracted from

  • Yonaha, K.; Suzuki, K.; Toyama, S.
    Streptomyces beta-alanine alpha-ketoglutarate aminotransferase, a novel omega-amino acid transaminase. Purification, crystallization, and enzymologic properties (1985), J. Biol. Chem., 260, 3265-3268 .
    View publication on PubMed
Search for more literature for 2.6.1.120

Inhibitors

Inhibitors Comment Organism Structure
alpha-fluoro-beta-alanine strong inhibition Streptomyces griseus
DL-gabaculine strong inhibition Streptomyces griseus
HgCl2 strong inhibition Streptomyces griseus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
8
-
 beta-Alanine pH not specified in the publication, temperature not specified in the publication Streptomyces griseus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
185000
-
 gel filtration Streptomyces griseus

Organism

Organism UniProt Comment Textmining
Streptomyces griseus
-
-
-
Streptomyces griseus IF0 3102
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces griseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
 Streptomyces griseus 4-oxobutanoate + L-glutamate
-
 ?
4-aminobutanoate + 2-oxoglutarate
-
 Streptomyces griseus IF0 3102 4-oxobutanoate + L-glutamate
-
 ?
beta-alanine + 2-oxoglutarate
-
 Streptomyces griseus 3-oxopropanoate + L-glutamate
-
 ?
beta-alanine + 2-oxoglutarate
-
 Streptomyces griseus IF0 3102 3-oxopropanoate + L-glutamate
-
 ?
DL-2-aminoisobutanoate + 2-oxoglutarate
-
 Streptomyces griseus 2-oxoisobutanoate + L-glutamate
-
 ?
DL-2-aminoisobutanoate + 2-oxoglutarate
-
 Streptomyces griseus IF0 3102 2-oxoisobutanoate + L-glutamate
-
 ?
hypotaurine + 2-oxoglutarate
-
 Streptomyces griseus ? + L-glutamate
-
 ?
hypotaurine + 2-oxoglutarate
-
 Streptomyces griseus IF0 3102 ? + L-glutamate
-
 ?
additional information enzyme catalyzes transamination of omega-amino acids including taurine and hypotaurine. beta-Alanine and DL-beta-aminoisobutanoate serve as a good amino donors, 2-oxoglutarate is the only amino acceptor, pyruvate and oxalacetate are inactive Streptomyces griseus ?
-
-
additional information enzyme catalyzes transamination of omega-amino acids including taurine and hypotaurine. beta-Alanine and DL-beta-aminoisobutanoate serve as a good amino donors, 2-oxoglutarate is the only amino acceptor, pyruvate and oxalacetate are inactive Streptomyces griseus IF0 3102 ?
-
-
taurine + 2-oxoglutarate
-
 Streptomyces griseus ? + L-glutamate
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 51000, SDS-PAGE Streptomyces griseus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate 4 mol/mol of enzyme Streptomyces griseus