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Literature summary for 2.6.1.120 extracted from

  • Fujimoto, S.; Mizutani, N.; Mizota, C.; Tamaki, N.
    The level of beta-alanine aminotransferase activity in regenerating and differentiating rat liver (1986), Biochim. Biophys. Acta, 882, 106-112 .
    View publication on PubMed
Search for more literature for 2.6.1.120

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
 2-oxoglutarate pH 8.8, 37°C Rattus norvegicus
6.3
-
 beta-Alanine pH 8.8, 37°C Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
105000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-aminopentanoate + 2-oxoglutarate Rattus norvegicus
-
 L-glutamate + 5-oxopentanoate
-
 ?
6-aminohexanoate + 2-oxoglutarate Rattus norvegicus
-
 L-glutamate + 6-oxohexanoate
-
 ?
beta-alanine + 2-oxoglutarate Rattus norvegicus
-
 3-oxopropanoate + L-glutamate
-
 ?
L-2-aminoisobutanoate + 2-oxoglutarate Rattus norvegicus
-
 2-oxoisobutanoate + L-glutamate
-
 ?
additional information Rattus norvegicus 4-aminobutanoate is also accepted as amino donor, reaction of EC 2.6.1.19. No donors: glycine, alanine, taurine, ornithine, spermine, spermidine, putrescine. Very poor acceptors: pyruvate, glyoxylate, oxaloacetate, phenylpyruvate ?
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver activity in regenerating rat liver is lower than that in control rat liver, activity is low in newborn rat liver and increases about 5fold, reaching the level observed in adult rat liver Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.408
-
 pH 8.8, 37°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-aminopentanoate + 2-oxoglutarate
-
 Rattus norvegicus L-glutamate + 5-oxopentanoate
-
 ?
6-aminohexanoate + 2-oxoglutarate
-
 Rattus norvegicus L-glutamate + 6-oxohexanoate
-
 ?
beta-alanine + 2-oxoglutarate
-
 Rattus norvegicus 3-oxopropanoate + L-glutamate
-
 ?
L-2-aminoisobutanoate + 2-oxoglutarate
-
 Rattus norvegicus 2-oxoisobutanoate + L-glutamate
-
 ?
additional information 4-aminobutanoate is also accepted as amino donor, reaction of EC 2.6.1.19. No donors: glycine, alanine, taurine, ornithine, spermine, spermidine, putrescine. Very poor acceptors: pyruvate, glyoxylate, oxaloacetate, phenylpyruvate Rattus norvegicus ?
-
-

Subunits

Subunits Comment Organism
dimer 2 * 56000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.2
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the liver enzyme transaminates from beta-alanine to 2-oxoglutaric acid, while the brain enzyme transaminates from gamma-aminobutyric acid, reaction of EC 2.6.1.19. beta-Alanine aminotransferase activity in regenerating rat liver is lower than that in control rat liver Rattus norvegicus