Literature summary for 2.6.1.118 extracted from

Horie, A.; Tomita, T.; Saiki, A.; Kono, H.; Taka, H.; Mineki, R.; Fujimura, T.; Nishiyama, C.; Kuzuyama, T.; Nishiyama, M.
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus (2009), Nat. Chem. Biol., 5, 673-679 .

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Organism

Organism	UniProt	Comment	Textmining
Thermus thermophilus	Q93R93	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[carrier protein LysW]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate	-	Thermus thermophilus	[carrier protein LysW]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate	-	?

General Information

General Information	Comment	Organism
physiological function	for the conversion of alpha-aminoadipate to lysine, the amino group of alpha-aminoadipate is modified by attachment to the gamma-carboxyl group of the C-terminal Glu54 of a small protein, LysW. The side chain of alpha-aminoadipate is converted to the lysyl side chain while still attached to LysW, and lysine is subsequently liberated from the LysW-lysine fusion	Thermus thermophilus

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Release 2023.1 (January 2023)