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Literature summary for 2.6.1.11 extracted from

  • Rajaram, V.; Prasad, K.; Ratna Prasuna, P.; Ramachandra, N.; Bharath, S.R.; Savithri, H.S.; Murthy, M.R.
    Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of the biosynthetic N-acetylornithine aminotransferases from Salmonella typhimurium and Escherichia coli (2006), Acta Crystallogr. Sect. F, 62, 980-983.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Salmonella enterica subsp. enterica serovar Typhimurium
expressed in Escherichia coli Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion in the presence of 1 mM 5-amino-1,3-cyclohexadienylcarboxylic acid Salmonella enterica subsp. enterica serovar Typhimurium
hanging drop vapour diffusion in the presence of 1 mM 5-amino-1,3-cyclohexadienylcarboxylic acid Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5-amino-1,3-cyclohexadienylcarboxylic acid potent inhibitor Escherichia coli
5-amino-1,3-cyclohexadienylcarboxylic acid potent inhibitor Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA affinity column chromatography Salmonella enterica subsp. enterica serovar Typhimurium
Ni-NTA affinity column chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate
-
 Salmonella enterica subsp. enterica serovar Typhimurium N2-acetyl-L-ornithine + 2-oxoglutarate
-
 ?
N-acetyl-L-glutamic gamma-semialdehyde + L-glutamate
-
 Escherichia coli N2-acetyl-L-ornithine + 2-oxoglutarate
-
 ?
N-succinyl-2-amino-6-oxopimelate + L-glutamate
-
 Escherichia coli N2-succinyl-1,6-diaminopimelate + 2-oxoglutarate
-
 ?

Synonyms

Synonyms Comment Organism
ACOAT
-
 Salmonella enterica subsp. enterica serovar Typhimurium
ACOAT
-
 Escherichia coli
N-acetylornithine aminotransferase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
N-acetylornithine aminotransferase
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent Salmonella enterica subsp. enterica serovar Typhimurium
pyridoxal 5'-phosphate dependent Escherichia coli