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Literature summary for 2.6.1.106 extracted from
- Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine (2007), Protein Sci., 16, 887-896.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Streptomyces venezuelae |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging drop method of vapor diffusion, three-dimensional structures of both the internal aldimine and the ketimine intermediate with glutamate are determined to 2.05 A resolution | Streptomyces venezuelae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate | Streptomyces venezuelae | the enzyme is involved in biosynthesis of desosamine | dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces venezuelae | Q9ZGH4 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces venezuelae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate | - |
Streptomyces venezuelae | dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate | - |
? | |
| dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate | the enzyme is involved in biosynthesis of desosamine | Streptomyces venezuelae | dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | DesV is a homodimer with each subunit containing 12 alpha-helical regions and 12 beta-strands that together form three layers of sheet | Streptomyces venezuelae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DesV | - |
Streptomyces venezuelae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | a pyridoxal-phosphate protein. The pyridoxal 5'-phosphate cofactor is held in place by residues contributed from both subunits (Asp164 and Gln167 from subunit I and Tyr221 and Asn235 from subunit II) | Streptomyces venezuelae | |
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Release 2023.1 (January 2023)
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