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Literature summary for 2.6.1.1 extracted from

  • Anglin, J.; Zavareh, R.B.; Sander, P.N.; Haldar, D.; Mullarky, E.; Cantley, L.C.; Kimmelman, A.C.; Lyssiotis, C.A.; Lairson, L.L.
    Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma (2018), Bioorg. Med. Chem. Lett., 28, 2675-2678 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-(2,4-dichlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
-
Homo sapiens
1-(4-chlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
-
Homo sapiens
1-biphenyl-2-yl-3-[2-(1H-indol-3-yl)ethyl]urea
-
Homo sapiens
1-[2-(1H-indol-3-yl)ethyl]-3-phenylurea
-
Homo sapiens
1-[2-(1H-indol-3-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]urea
-
Homo sapiens
1-[2-(1H-indol-3-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]urea
-
Homo sapiens
4-(1H-indazol-4-yl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(2-methylphenyl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(3-methylphenyl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(3-phenoxyphenyl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(4-methylphenyl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(propan-2-yl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(pyridazin-4-yl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-(pyrimidin-5-yl)piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-[3-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-[4-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
-
Homo sapiens
4-(1H-indol-4-yl)-N-[4-(trifluoromethyl)phenyl]piperazine-1-carboxamide
-
Homo sapiens
4-(3-methoxyphenyl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(5-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(6-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(6-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(7-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(7-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-(methylsulfonyl)-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
4-acetyl-N-phenylpiperazine-1-carboxamide
-
Homo sapiens
N,4-diphenylpiperazine-1-carboxamide
-
Homo sapiens
N-(1,3-benzothiazol-5-yl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-(2,4-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-(2-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-(3,5-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-(3-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-(4-benzoylphenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-phenyl-4-(propan-2-yl)piperazine-1-carboxamide
-
Homo sapiens
N-phenyl-4-(pyridin-4-yl)piperazine-1-carboxamide
-
Homo sapiens
N-phenyl-4-(quinolin-5-yl)piperazine-1-carboxamide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate + 2-oxoglutarate Homo sapiens
-
oxaloacetate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17174
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic ductal adenocarcinoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate + 2-oxoglutarate
-
Homo sapiens oxaloacetate + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
aspartate aminotransferase 1
-
Homo sapiens
glutamate-oxaloacetate transaminase 1
-
Homo sapiens
GOT1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0082
-
at 37°C, pH not specified in the publication Homo sapiens N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
0.014
-
at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
0.016
-
at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-[4-(trifluoromethyl)phenyl]piperazine-1-carboxamide
0.022
-
at 37°C, pH not specified in the publication Homo sapiens N-(3,5-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
0.032
-
at 37°C, pH not specified in the publication Homo sapiens 1-(2,4-dichlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
0.034
-
at 37°C, pH not specified in the publication Homo sapiens 1-biphenyl-2-yl-3-[2-(1H-indol-3-yl)ethyl]urea
0.036
-
at 37°C, pH not specified in the publication Homo sapiens 1-(4-chlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
0.039
-
at 37°C, pH not specified in the publication Homo sapiens 1-[2-(1H-indol-3-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]urea
0.039
-
at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(3-phenoxyphenyl)piperazine-1-carboxamide
0.041
-
at 37°C, pH not specified in the publication Homo sapiens 4-(7-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.043
-
at 37°C, pH not specified in the publication Homo sapiens N-(4-benzoylphenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
0.046
-
at 37°C, pH not specified in the publication Homo sapiens 4-(6-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.052
-
at 37°C, pH not specified in the publication Homo sapiens N-(3-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
0.056
-
at 37°C, pH not specified in the publication Homo sapiens N-(2,4-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
0.062
-
at 37°C, pH not specified in the publication Homo sapiens 1-[2-(1H-indol-3-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]urea
0.076
-
at 37°C, pH not specified in the publication Homo sapiens N-(1,3-benzothiazol-5-yl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
0.085
-
at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 1-[2-(1H-indol-3-yl)ethyl]-3-phenylurea
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indazol-4-yl)-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(2-methylphenyl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(3-methylphenyl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(4-methylphenyl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(propan-2-yl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(pyridazin-4-yl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-(pyrimidin-5-yl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-[3-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(1H-indol-4-yl)-N-[4-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(3-methoxyphenyl)-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(5-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(6-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(7-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-(methylsulfonyl)-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens 4-acetyl-N-phenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens N,4-diphenylpiperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens N-(2-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens N-phenyl-4-(propan-2-yl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens N-phenyl-4-(pyridin-4-yl)piperazine-1-carboxamide
0.1
-
IC50 above 0.1 mM, at 37°C, pH not specified in the publication Homo sapiens N-phenyl-4-(quinolin-5-yl)piperazine-1-carboxamide