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Literature summary for 2.5.1.91 extracted from

  • Saiki, R.; Nagata, A.; Kainou, T.; Matsuda, H.; Kawamukai, M.
    Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans (2005), FEBS J., 272, 5606-5622.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information human DLP1 is not able to complement a Schizosaccharomyces dpl1 disruptant. Escherichia coli double transformants expressing human DPS1 and DLP1 produce coenzyme Q10, and an in vitro activity of decaprenyl diphosphate synthase can be verified. Expression in Escherichia coli of heterologous combinations, human DLP1 and mouse DPS1, generates both Q9 and Q10, indicating both components are involved in determining the ubiquinone side chain Homo sapiens
additional information human DPS1 is able to complement a Schizosaccharomyces dps1 disruptant. Escherichia coli transformants expressing human DPS1 produce only coenzyme Q8 of Escherichia coli origin, double transformants expressing human DPS1 and DLP1 produce Q10, and an in vitro activity of decaprenyl diphosphate synthase can be verified. Expression in Escherichia coli of heterologous combinations, human DPS1 and mouse DLP1, generates both Q9 and Q10, indicating both components are involved in determining the ubiquinone side chain Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5T2R2 subunit DPS1
-
Homo sapiens Q5T2R2 and Q86YH6 Q5T2R2: subunit 1 (DPS1) and Q86YH6: subunit 2 (DLP1/PDSS2)
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Homo sapiens Q86YH6 subunit DLP1
-

Subunits

Subunits Comment Organism
heterotetramer heterotetramer of 2 DPS1 and 2 DLP1 subunits, both components are involved in determining the length of the ubiquinone side chain Homo sapiens
tetramer 2 * Dps1 + 2 * Dlp1, gel filtration and calculated Homo sapiens

Synonyms

Synonyms Comment Organism
decaprenyl diphosphate synthase
-
Homo sapiens