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Literature summary for 2.5.1.87 extracted from
- In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system (2004), Biochem. Biophys. Res. Commun., 318, 198-203.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DedolPP synthase | - |
Homo sapiens |
| dehydrodolichyl diphosphate synthase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | dehydrodolichyl diphosphate synthase catalyzes the sequential condensation of isopentenyl diphosphate with farnesyl diphosphate to synthesize dehydrodolichyl diphosphate, a biosynthetic precursor for dolichol which plays an important role as a sugar-carrier lipid in the biosynthesis of glycoprotein in eukaryotic cells. Identification of a specific interaction of human dehydrodolichyl diphosphate synthase with the NiemannPick Type C2 protein (NPC2/HE1), whose defects cause NiemannPick type C2 disease | Homo sapiens |
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Release 2023.1 (January 2023)
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