Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli as a glutathione S-transferase fusion protein | Aeropyrum pernix |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate | Aeropyrum pernix | Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aeropyrum pernix | Q9UWR6 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Aeropyrum pernix |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate | Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids | Aeropyrum pernix | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate | farnesyl diphosphate is the allylic substrate with the highest activity | Aeropyrum pernix | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate | - |
? | |
dimethylallyl diphosphate + 4 isopentenyl diphosphate | dimethylallyl diphosphate shows 28% of the activity with farnesyl diphosphate | Aeropyrum pernix | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate | large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate | ? | |
geranyl diphosphate + 3 isopentenyl diphosphate | geranyl diphosphate shows 72% of the activity with farnesyl diphosphate | Aeropyrum pernix | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate | - |
? | |
geranylgeranyl diphosphate + isopentenyl diphosphate | geranylgeranyl diphosphate shows 65% of the activity with farnesyl diphosphate | Aeropyrum pernix | (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C25 farnesylgeranyl diphosphate synthase | - |
- |
farnesylgeranyl diphosphate synthase | - |
- |
FGPP synthase | - |
Aeropyrum pernix |
Fgs | - |
Aeropyrum pernix |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Aeropyrum pernix |