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Literature summary for 2.5.1.78 extracted from

  • Klinke, S.; Zylberman, V.; Vega, D.R.; Guimaraes, B.G.; Braden, B.C.; Goldbaum, F.A.
    Crystallographic studies on decameric Brucella spp. lumazine synthase: a novel quaternary arrangement evolved for a new function? (2005), J. Mol. Biol., 353, 124-137.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystals are obtained by means of the hanging-drop, vapor-diffusion method at room temperature Brucella sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate Brucella sp. the pathogen Brucella spp. expresses two proteins that exhibit lumazine synthase activity, RibH1 and RibH2. RibH1 appears to be the functional lumazine synthase in Brucella spp., whereas RibH2, an enzyme of lower catalytic activity, is a virulence factor presumably acting in response to oxidative stress 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
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 ?

Organism

Organism UniProt Comment Textmining
Brucella sp.
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate
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 Brucella sp. 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
-
 ?
5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate the pathogen Brucella spp. expresses two proteins that exhibit lumazine synthase activity, RibH1 and RibH2. RibH1 appears to be the functional lumazine synthase in Brucella spp., whereas RibH2, an enzyme of lower catalytic activity, is a virulence factor presumably acting in response to oxidative stress Brucella sp. 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O
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 ?

Subunits

Subunits Comment Organism
decamer a head-to-head oriented dimer of pentamers. pH plays a critical role in the structure of the interface between pentamers in Brucella spp. RibH2 Brucella sp.

Synonyms

Synonyms Comment Organism
RibH2
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 Brucella sp.