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Literature summary for 2.5.1.7 extracted from
- MurAA is required for intrinsic cephalosporin resistance of Enterococcus faecalis (2012), Antimicrob. Agents Chemother., 56, 2443-2451.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in an Enterococcus faecalis mutant lacking IreK (formerly PrkC), a key kinase required for cephalosporin resistance, and in Escherichia coli BL21(DE3) cells | Enterococcus faecalis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C120S | catalytically inactive | Enterococcus faecalis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| nickel affinity column chromatography | Enterococcus faecalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Enterococcus faecalis | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MurAA | - |
Enterococcus faecalis |
| UDP-N-acetylglucosamine 1-carboxyvinyl transferase | - |
Enterococcus faecalis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | frame deletion of murAA leads to increased susceptibility of Enterococcus faecalis to the cephalosporins ceftriaxone and ceftazidime | Enterococcus faecalis |
| physiological function | the enzyme is necessary but not sufficient for intrinsic cephalosporin resistance of Enterococcus faecalis | Enterococcus faecalis |
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Release 2023.1 (January 2023)
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