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Literature summary for 2.5.1.66 extracted from

  • Khaleeli, N.; Li, R.; Townsend, C.A.
    Origin of the b-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction (1999), J. Am. Chem. Soc., 121, 9223-9224.
No PubMed abstract available
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptomyces clavuligerus first enzyme of the clavulanic acid gene cluster ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
D-glyceraldehyde 3-phosphate + L-arginine = N2-(2-carboxyethyl)-L-arginine + phosphate mechanism Streptomyces clavuligerus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + L-arginine mechanism Streptomyces clavuligerus N2-(2-carboxyethyl)-L-arginine + phosphate
-
 ?
additional information first enzyme of the clavulanic acid gene cluster Streptomyces clavuligerus ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate absolute requirement Streptomyces clavuligerus