Protein Variants | Comment | Organism |
---|---|---|
H145Y | spontaneous mutant, excretes a large amount of a red compound identified as coproporphyrin III. The mutant is able to grow under phototrophic conditions but has low levels of intracellular cysteine and glutathione and overexpresses the cysteine synthase CysK. The wild-type phenotype is restored when the gene metK encoding SAM synthetase is supplied in trans. The mutation is responsible for a 70% decrease in intracellular SAM content which probably affects the activities of numerous SAM-dependent enzymes such as coproporphyrinogen oxidase, uroporphyrinogen III methyltransferase, and molybdenum cofactor biosynthesis protein A | Cereibacter sphaeroides |
Organism | UniProt | Comment | Textmining |
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Cereibacter sphaeroides | C8ZLJ7 | - |
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