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Literature summary for 2.5.1.6 extracted from

  • Ramani, K.; Yang, H.; Kuhlenkamp, J.; Tomasi, L.; Tsukamoto, H.; Mato, J.M.; Lu, S.C.
    Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation (2010), Hepatology, 51, 986-995.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Homo sapiens
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liver
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 Rattus norvegicus
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LX-2 cell
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 Homo sapiens
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stellate cell isoforms MAT2AandMAT2beta are induced in culture-activated primary hepatic stellate cells and hepatic stellate cells from 10-day bile duct ligated rat livers. Hepatic stellate cell activation leads to a decline in intracellular S-adenosylmethionine and methyhthioadenosine levels, a drop in the S-adenosylmethionine/S-adenosylhomocysteine ratio, and global DNA hypomethylation. The decrease in S-adenosylmethionen levels is associated with lower MATII activity during activation Rattus norvegicus
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General Information

General Information Comment Organism
physiological function MAT2A or MAT2beta silencing results in decreased collagen and alpha-smooth muscle actin expression and cell growth and increased apoptosis. MAT2A knockdown decreases intracellular S-adenosylmethionine levels in LX-2 cells. Activation of extracellular signal-regulated kinase and phosphatidylinositol-3-kinase signaling in LX-2 cells requires the expression of MAT2 but not that of MAT2A Homo sapiens
physiological function MAT2A silencing in primary heaptic stellate cells results in decreased collagen and alpha-smooth muscle actin expression and cell growth and increased apoptosis Rattus norvegicus