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Literature summary for 2.5.1.6 extracted from
- An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations (2009), Arch. Biochem. Biophys., 492, 82-92.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Escherichia coli |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| quantum mechanical/molecular mechanical calculations, exploiting structures of the active crystalline enzyme, based on PDB files 1P7L and 1RG9 | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0A817 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine | catalysis of a SN2 reaction through hydrogen bonding of the liberated oxygen-5' to the histidine, charge neutralization by the two Mg2+ ions, and stabilization of the product sulfonium cation through a close, non-bonded, contact between the sulfur and the ribose oxygen-4' | Escherichia coli |
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