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Literature summary for 2.5.1.6 extracted from

  • Rodriguez, J.L.; Boukaba, A.; Sandoval, J.; Georgieva, E.I.; Latasa, M.U.; Garcia-Trevijano, E.R.; Serviddio, G.; Nakamura, T.; Avila, M.A.; Sastre, J.; Torres, L.; Mato, J.M.; Lopez-Rodas, G.
    Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells (2007), Int. J. Biochem. Cell Biol., 39, 842-850.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
E2F1 present continually in the MAT2A promoter during liver regeneration Rattus norvegicus
E2F3 present continually in the MAT2A promoter during liver regeneration Rattus norvegicus
E2F4 present continually in the MAT2A promoter during liver regeneration Rattus norvegicus
Sp1 binding of Sp1 to the MAT2A promoter is essential for the transcriptional up-regulation of the gene Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P18298
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte adult quiescent hepatocyte Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
 Rattus norvegicus phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Synonyms

Synonyms Comment Organism
MAT II isozyme Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus