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Literature summary for 2.5.1.6 extracted from

  • Chen, H.; Xia, M.; Lin, M.; Yang, H.; Kuhlenkamp, J.; Li, T.; Sodir, N.M.; Chen, Y.H.; Josef-Lenz, H.; Laird, P.W.; Clarke, S.; Mato, J.M.; Lu, S.C.
    Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells (2007), Gastroenterology, 133, 207-218.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Epidermal growth factor 100 ng/ml upregulates MAT2A (but not MAT2beta) expression Homo sapiens
Epidermal growth factor 100 ng/ml upregulates MAT2A (but not MAT2beta) expression Mus musculus
insulin-like growth factor 1 100 ng/ml upregulates MAT2A (but not MAT2beta) expression Homo sapiens
insulin-like growth factor 1 100 ng/ml upregulates MAT2A (but not MAT2beta) expression Mus musculus
leptin 100 ng/ml upregulates MAT2A (but not MAT2beta) expression Homo sapiens
leptin 100 ng/ml upregulates MAT2A (but not MAT2beta) expression Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
methylthioadenosine 1 mM downregulates MAT2A expression Mus musculus
S-adenosylmethionine 5 mM downregulates MAT2A expression Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q3TH56
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
RKO cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
Homo sapiens phosphate + diphosphate + S-adenosyl-L-methionine
-
?
ATP + L-methionine + H2O
-
Mus musculus phosphate + diphosphate + S-adenosyl-L-methionine
-
?

Synonyms

Synonyms Comment Organism
MAT2A
-
Homo sapiens
MAT2A
-
Mus musculus
methionine adenosyltransferase 2A
-
Homo sapiens
methionine adenosyltransferase 2A
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Mus musculus