Literature summary for 2.5.1.6 extracted from

Driskell, L.O.; Tucker, A.M.; Winkler, H.H.; Wood, D.O.
Rickettsial metK-encoded methionine adenosyltransferase expression in an Escherichia coli metK deletion strain (2005), J. Bacteriol., 187, 5719-5722.

Search for more literature for 2.5.1.6

Cloned(Commentary)

Cloned (Comment)	Organism
gene metK, DNA and amino acid sequence determination and analysis, expression in and complementation of an Escherichia coli metK deletion strain	Rickettsia prowazekii
gene metK, DNA and amino acid sequence determination and analysis, expression in and complementation of an Escherichia coli metK deletion strain	Rickettsia typhi
gene metK, expression in a metK deletion mutant Escherichia coli strain MOB1490	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a metK deletion mutant strain MOB1490 from wild-type strain BW25113, complementation by wild-type gene metK, as well as by genes metK from Rickettsia prowazekii and Rickettsia typhi, overview	Escherichia coli
additional information	mutations that affect the function of the metK gene products are a stop codon in the Madrid E strain and a 6-bp deletion in the Breinl strain, these typhus group genes, like the more degenerate spotted fever group orthologs, are in the process of gene degradation, overview	Rickettsia prowazekii

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Escherichia coli
Mg2+	-	Rickettsia prowazekii
Mg2+	-	Rickettsia typhi

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-methionine + H2O	Escherichia coli	-	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	Rickettsia prowazekii	-	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	Rickettsia typhi	typhus group rickettsiae have the capability of synthesizing as well as transporting SAM	phosphate + diphosphate + S-adenosyl-L-methionine	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	gene metK, strain BW25113	-
Rickettsia prowazekii	-	gene metK, fever group, Breinl and Madrid E strains	-
Rickettsia typhi	-	gene metK, strain Wilmington of the typhus group rickettsiae	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-methionine + H2O	-	Escherichia coli	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	-	Rickettsia prowazekii	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	-	Rickettsia typhi	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	typhus group rickettsiae have the capability of synthesizing as well as transporting SAM	Rickettsia typhi	phosphate + diphosphate + S-adenosyl-L-methionine	-	?

Synonyms

Synonyms	Comment	Organism
MAT	-	Escherichia coli
MAT	-	Rickettsia prowazekii
MAT	-	Rickettsia typhi

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Escherichia coli
ATP	-	Rickettsia prowazekii
ATP	-	Rickettsia typhi

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Release 2023.1 (January 2023)