Literature summary for 2.5.1.6 extracted from

Lu, S.C.; Mato, J.M.
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer (2005), Alcohol, 35, 227-234.

Search for more literature for 2.5.1.6

Application

Application	Comment	Organism
medicine	animals fed ethanol intragastrically for 9 weeks switch hepatic MAT expression from MAT1A to MAT2A followed by decrease in S-adenosylmethionine levels, hypomethylation of c-myc, increase in c-myc expression and increased DNA strand break accumulation	Rattus norvegicus
medicine	MAT1A knockout mice, spontaneous steatohepatitis develops by 8 months, hepatocellular carcinoma develops by 18 months	Rattus norvegicus
medicine	patients with acoholic liver disease, decrease in hepatic enzyme activity due to decreased MAT1A expression and inactivation of MAT1A-encoded isoenzymes	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	MAT1A knockout mice, spontaneous steatohepatitis develops by 8 months, hepatocellular carcinoma develops by 18 months	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoforms MAT1A, MAT2A	-
Rattus norvegicus	-	isoforms MAT1A, MAT2A	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	hepatocellular carcinoma, MAT1A is replaced by MAT2A	Homo sapiens	-
liver	predominant expression of MAT1A, induction of MAT2A during periods of rapid growth and dedifferentiaition	Rattus norvegicus	-
liver	predominant expression of MAT1A, induction of MAT2A during periods of rapid growth and dedifferentiation	Homo sapiens	-
liver	predominant expression of MAT1A, induction of MAT2A during periods of rapid growth and dedifferentiation	Rattus norvegicus	-

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Release 2023.1 (January 2023)