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Literature summary for 2.5.1.6 extracted from

  • De La Rosa, J.; Ostrowski, J.; Hryniewicz, M.M.; Kredich, N.M.; Kotb, M.; LeGros, H.L., Jr.; Valentine, M.; Geller, A.M.
    Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase (1995), J. Biol. Chem., 270, 21860-21868.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
alpha subunit expressed in Escherichia coli NM522 strain Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
L-methionine uninduced E. coli NM522 strain extract alpha subunit at low L-methionine concentrations Homo sapiens
0.08
-
L-methionine induced E. coli NM522 strain extract alpha subunit at low L-methionine concentrations and uninduced E. coli NM522 strain extract alpha subunit at high L-methionine concentrations Homo sapiens
0.2
-
L-methionine induced E. coli NM522 strain extract alpha subunit at high L-methionine concentrations Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
expression of the alpha subunit in E. coli, gel filtration Homo sapiens
53000
-
expression of the alpha subunit in E. coli, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
Homo sapiens S-adenosyl-L-methionine + phosphate + diphosphate
-
?

Subunits

Subunits Comment Organism
More alpha subunit from human kidney and normal or malignant lymphocytes is identical. Alpha subunit expressed in human liver. Alpha subunit is the catalytic subunit whereas beta subunit may have a regulatory function Homo sapiens