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Literature summary for 2.5.1.6 extracted from

  • Yarlett, N.; Garofalo, J.; Goldberg, B.; Ciminelli, M.A.; Ruggiero, V.; Sufrin, J.R.; Bacchi, C.J.
    S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei (1993), Biochim. Biophys. Acta, 1181, 68-76.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cycloleucine
-
Trypanosoma brucei brucei
D-methionine
-
Trypanosoma brucei brucei
Dimethylsulfoxide
-
Trypanosoma brucei brucei
DL-Ethionine
-
Trypanosoma brucei brucei
L-2-Amino-4-methoxy-cis-but-3-enoic acid
-
Trypanosoma brucei brucei
Mg2+ inhibitory above 8.5 mM Trypanosoma brucei brucei
Mn2+ inhibition in presence of Mg2+ Trypanosoma brucei brucei
Na+ in presence of Mg2+ Trypanosoma brucei brucei
S-adenosyl-L-homocysteine
-
Trypanosoma brucei brucei
S-adenosylmethionine
-
Trypanosoma brucei brucei
seleno-L-methionine
-
Trypanosoma brucei brucei
Sodium diphosphate
-
Trypanosoma brucei brucei

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement Trypanosoma brucei brucei
Mn2+ can partially replace Mg2+ in activation, inhibition in presence of Mg2+ Trypanosoma brucei brucei
Na+ slight activation in absence of Mg2+ Trypanosoma brucei brucei

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
145000
-
gel filtration Trypanosoma brucei brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Trypanosoma brucei brucei used as aminopropyl group donor in synthesis of polyamines and is also the methyl group donor for most cellular methyltransferase reactions S-adenosyl-L-methionine + phosphate + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei brucei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Trypanosoma brucei brucei

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Trypanosoma brucei brucei
0.00278
-
-
Trypanosoma brucei brucei

Storage Stability

Storage Stability Organism
-70°C, 63% loss of activity after 3 days Trypanosoma brucei brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-ATP + L-methionine + H2O
-
Trypanosoma brucei brucei ?
-
?
3'-deoxy-ATP + L-methionine + H2O
-
Trypanosoma brucei brucei ?
-
?
ATP + L-ethionine + H2O
-
Trypanosoma brucei brucei S-adenosyl-L-ethionine + phosphate + diphosphate
-
?
ATP + L-methionine + H2O
-
Trypanosoma brucei brucei S-adenosyl-L-methionine + phosphate + diphosphate
-
?
ATP + L-methionine + H2O used as aminopropyl group donor in synthesis of polyamines and is also the methyl group donor for most cellular methyltransferase reactions Trypanosoma brucei brucei S-adenosyl-L-methionine + phosphate + diphosphate
-
?
additional information ATP can be substituted by 3'-deoxy-ATP,8-bromo-ATP, formycin triphosphate, adenyl-5'yl imidodiphosphate Trypanosoma brucei brucei ?
-
?
additional information methionine can be substituted by selenomethionine, alpha-methyl-DL-methionine Trypanosoma brucei brucei ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Trypanosoma brucei brucei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
slight variation in activity between 8 and 10 Trypanosoma brucei brucei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.24
-
S-adenosylmethionine
-
Trypanosoma brucei brucei
0.4
-
D-methionine
-
Trypanosoma brucei brucei
0.51
-
seleno-L-methionine
-
Trypanosoma brucei brucei
0.71
-
DL-Ethionine
-
Trypanosoma brucei brucei
1.6
-
Sodium diphosphate
-
Trypanosoma brucei brucei
17
-
cycloleucine
-
Trypanosoma brucei brucei
250
-
Na+ in presence of Mg2+ Trypanosoma brucei brucei