Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.59 extracted from

  • Epifano, F.; Curini, M.; Genovese, S.; Blaskovich, M.; Hamilton, A.; Sebti, S.M.
    Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I (2007), Bioorg. Med. Chem. Lett., 17, 2639-2642.
    View publication on PubMed
Search for more literature for 2.5.1.59

Activating Compound

Activating Compound Comment Organism Structure
7-isopentenyloxycoumarin 0.1 mM, 10.3% activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-(4'-farnesyloxy-3'-methoxyphenyl)-2-trans propenoic acid 0.1 mM, 83.9% inhibition Homo sapiens
3-(4'-farnesyloxy-3'-OH-phenyl)-2-trans propenoic acid 0.1 mM, 93.5% inhibition Homo sapiens
3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid 0.1 mM, 78.6% inhibition Homo sapiens
3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid ethyl ester 0.1 mM, 3% inhibition Homo sapiens
3-(4'-geranyloxy-3'-OH-phenyl)-2-trans propenoic acid 0.1 mM, 72.4% inhibition Homo sapiens
3-(4'-geranyloxy-3'-OH-phenyl)-2-trans propenoic acid ethyl ester 0.1 mM, 7.5% inhibition Homo sapiens
3-(4'-isopentenyloxy-3'-OH-phenyl)-2-trans propenoic acid 0.1 mM, 46.4% inhibition Homo sapiens
auraptene 0.1 mM, 18.6% inhibition Homo sapiens
boropinic acid 0.1 mM, 31% inhibition Homo sapiens
collinin 0.1 mM, 34.2% inhibition Homo sapiens
additional information not inhibited by valencic acid, 4'-geranyloxybenzoic acid, 4-isopentenyloxy-3-methoxy benzoic acid, and 4-geranyloxy-3-methoxy benzoic acid Homo sapiens
umbelliprenine 0.1 mM, 13.4% inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
geranylgeranyltransferase I
-
 Homo sapiens
GGTase I
-
 Homo sapiens