Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.58 extracted from

  • Aboelfotoh Hendy, A.; Xing, J.; Chen, X.; Chen, X.L.
    The farnesyltransferase beta-subunit RAM1 regulates localization of RAS proteins and appressorium-mediated infection in Magnaporthe oryzae (2019), Mol. Plant Pathol., 20, 1264-1278 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Pyricularia oryzae G4MY67 beta-subunit Ram1
-
Pyricularia oryzae ATCC MYA-4617 G4MY67 beta-subunit Ram1
-

Synonyms

Synonyms Comment Organism
Ram1
-
Pyricularia oryzae

General Information

General Information Comment Organism
physiological function targeted disruption of beta-subunit RAM1 results in the reduction of hyphal growth and sporulation, and an increase in the sensitivity to various stresses. Loss of RAM1 also leads to the attenuation of virulence on the plant host, decreased appressorium formation and invasive growth. Ras GTPases, RAS1 and RAS2, can interact with Ram1, and their plasma membrane localization is regulated by Ram1 through their C-terminal farnesylation sites. Adding farnesyltransferase inhibitor Tipifarnib can result in similar defects as in a Ram1 deletion mutant, including decreased appressorium formation and invasive growth Pyricularia oryzae