Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pyricularia oryzae | G4MY67 | beta-subunit Ram1 | - |
Pyricularia oryzae ATCC MYA-4617 | G4MY67 | beta-subunit Ram1 | - |
Synonyms | Comment | Organism |
---|---|---|
Ram1 | - |
Pyricularia oryzae |
General Information | Comment | Organism |
---|---|---|
physiological function | targeted disruption of beta-subunit RAM1 results in the reduction of hyphal growth and sporulation, and an increase in the sensitivity to various stresses. Loss of RAM1 also leads to the attenuation of virulence on the plant host, decreased appressorium formation and invasive growth. Ras GTPases, RAS1 and RAS2, can interact with Ram1, and their plasma membrane localization is regulated by Ram1 through their C-terminal farnesylation sites. Adding farnesyltransferase inhibitor Tipifarnib can result in similar defects as in a Ram1 deletion mutant, including decreased appressorium formation and invasive growth | Pyricularia oryzae |